Association of triage #hypothermia with in-hospital mortality among patients in the emergency department with suspected #sepsis

To identify if triage hypothermia (<36.0 °C) among emergency department (ED) encounters with sepsis are independently associated with mortality.. ..Of 1.2 billion ED encounters (95% confidence interval [CI] 1.0–1.3 billion), 3.1 million (95% CI 2.7–3.5 million) met the explicit sepsis definition; 7.4% (95% CI 75.2–9.7%) had triage hypothermia. The adjusted odds ratio (aOR) for hypothermia for in-hospital mortality was 6.82 (95% CI 3.08–15.22). The severe … Continue reading Association of triage #hypothermia with in-hospital mortality among patients in the emergency department with suspected #sepsis

#Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke

Human neutrophils are the most abundant circulating leukocytes and contribute to acute and chronic inflammatory disorders. Neutrophil apoptosis is programed cell death to maintain immune homeostasis, but inflammatory responses to infections or tissue injury disrupt neutrophil death program, leading to many diseases. Precise control of neutrophil apoptosis may resolve inflammation to return immune homeostasis. Here, we report a method in which doxorubicin (DOX)–conjugated protein nanoparticles … Continue reading #Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke