Associations between Serum Levels of #Cholesterol and #survival to Age 90 in Postmenopausal Women

Although elevated lipid levels predict increased risk of coronary heart disease and death in middle‐aged women and men, evidence is mixed if lipid levels measured in later life predict survival to very old ages.. HDL and LDL levels were not associated with survival to age 90 after adjustment for cardiovascular risk factors.. Similarly, no associations were observed between HDL and LDL levels and survival to … Continue reading Associations between Serum Levels of #Cholesterol and #survival to Age 90 in Postmenopausal Women

Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity

..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signalling and replicated the findings in TCGA … Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity

Dog Ownership and #Survival A Systematic Review and Meta-Analysis

Dog ownership has been associated with decreased cardiovascular risk. Recent reports have suggested an association of dog companionship with lower blood pressure levels, improved lipid profile, and diminished sympathetic responses to stress. Dog ownership was associated with a 24% risk reduction for all-cause mortality as compared to nonownership (relative risk, 0.76; 95% CI, 0.67–0.86) with 6 studies demonstrating significant reduction in the risk of death. … Continue reading Dog Ownership and #Survival A Systematic Review and Meta-Analysis