Background: Long-term exposure to air pollution concentrations is known to be adversely associated with a broad range of single non-communicable diseases, but its role in multimorbidity has not been investigated in the UK. We aimed to assess associations between long-term air pollution exposure and multimorbidity status, severity, and patterns using the UK Biobank cohort. Methods:… Continue reading Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study
Association between vitamin D supplementation and COVID-19 infection and mortality
Vitamin D deficiency has long been associated with reduced immune function that can lead to viral infection. Several studies have shown that Vitamin D deficiency is associated with increases the risk of infection with COVID-19. However, it is unknown if treatment with Vitamin D can reduce the associated risk of COVID-19 infection, which is the… Continue reading Association between vitamin D supplementation and COVID-19 infection and mortality
Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis
ContextExcess calories from free sugars are implicated in the epidemics of obesity and type 2 diabetes. Honey is a free sugar but is generally regarded as healthy.ObjectiveThe effect of honey on cardiometabolic risk factors was assessed via a systematic review and meta-analysis of controlled trials using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation)… Continue reading Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis
Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities
APOE-ɛ4, late life cognitive activity, physical activity, and smoking, total flavonol intake was associated with slower decline in global cognition β estimate=0.004 (95% CI=0.001, 0.006), episodic memory β=0.004 (95% CI: 0.002, 0.006), semantic memory β=0.003 (95% CI: 0.001, 0.007), perceptual speed β=0.003 (95% CI: 0.001, 0.004), and working memory β=0.003 (95% CI: 0.001, 0.005) and… Continue reading Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities
Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being
Background High blood pressure is a leading cardiovascular disease risk factor and considered to be associated with psychological factors. However, the causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being are not clear.Aims The current study explored the genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.Methods Mendelian randomisation… Continue reading Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being
Persistent Asthma Is Associated With Carotid Plaque in MESA
BackgroundAsthma and atherosclerotic cardiovascular disease share an underlying inflammatory pathophysiology. We hypothesized that persistent asthma is associated with carotid plaque burden, a strong predictor of atherosclerotic cardiovascular disease events.Methods and ResultsThe MESA (Multi‐Ethnic Study of Atherosclerosis) enrolled adults free of known atherosclerotic cardiovascular disease at baseline. Subtype of asthma was determined at examination 1. Persistent… Continue reading Persistent Asthma Is Associated With Carotid Plaque in MESA
Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
AbstractAsymptomatic blood donors can transmit human parvovirus B19 (B19V). We assessed the B19V prevalence amongst a large cohort of blood donations collected in Germany during 2015-2018. In total, 167,123 donations were screened for B19V DNA with 22 cases of viraemia identified (0.013% positive). Infections peaked at a four-year interval and the highest number of cases… Continue reading Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
Community-level age bias and older adult mortality
As the older adult population increases, understanding the health effects of bias against older adults is increasingly important. Whether structural forms of age bias predict worse health has received limited attention.ObjectiveWe hypothesized that communities with greater age bias would have higher mortality among residents aged 65 and older. We expected the association to be unique… Continue reading Community-level age bias and older adult mortality
Low-Energy Dense Potato- and Bean-Based Diets Reduce Body Weight and Insulin Resistance: A Randomized, Feeding, Equivalence Trial
AbstractWe evaluated the effect of diets low in energy density (1 kcal/g) and high in either potatoes (Potato) or pulses (Bean) on blood glucose control in participants with insulin resistance. We hypothesized that the Potato and Bean diets would have equivalent effects. This was an 8-week randomized, parallel design, controlled feeding study comparing Potato and… Continue reading Low-Energy Dense Potato- and Bean-Based Diets Reduce Body Weight and Insulin Resistance: A Randomized, Feeding, Equivalence Trial
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