Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis

To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. Design Systematic review and individual patient data meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Ovid Medline, Ovid Embase, EBSCO CINAHL Plus, and Web of Science. Eligibility criteria for study selection Randomised controlled trials … Continue reading Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis

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Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled … Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

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#Meningeal γδ T cells regulate #anxiety-like behavior via IL-17a signaling in neurons

Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Studies suggest that IL-17a promotes behavioral changes in experimental models of autism and aggregation behavior in worms. Here, through a cellular and molecular characterization of meningeal γδ17 T cells, we defined the nearest central nervous system–associated source of IL-17a under homeostasis. Meningeal γδ … Continue reading #Meningeal γδ T cells regulate #anxiety-like behavior via IL-17a signaling in neurons

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Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis

Low-dose glucocorticoids are frequently used for the management of rheumatoid arthritis (RA) and other chronic conditions, but the safety of long-term use remains uncertain.. ..Associations between glucocorticoid dose (none, ≤5 mg/d, >5 to 10 mg/d, and >10 mg/d) and hospitalized infection were evaluated using inverse probability–weighted analyses, with 1-year cumulative incidence predicted from weighted models. Results: 247 297 observations were identified among 172 041 patients … Continue reading Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis

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Co‐occurrence of #antibiotic, biocide, and heavy #metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site

Contaminants such as heavy metals may contribute to the dissemination of antimicrobial resistance (AMR) by enriching resistance gene determinants via co‐selection mechanisms. In the present study, a survey was performed on soils collected from four areas at the Savannah River Site (SRS), South Carolina, USA, with varying contaminant profiles: relatively pristine (Upper Three Runs), heavy metals (Ash Basins), radionuclides (Pond B) and heavy metal and … Continue reading Co‐occurrence of #antibiotic, biocide, and heavy #metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site

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Effectiveness of #honey for symptomatic relief in upper #respiratory tract infections: a systematic review and meta-analysis

Antibiotic over prescription for upper respiratory tract infections (URTIs) in primary care exacerbates antimicrobial resistance. There is a need for effective alternatives to antibiotic prescribing. Honey is a lay remedy for URTIs, and has an emerging evidence base for its use. Honey has antimicrobial properties, and guidelines recommended honey for acute cough in children.. ..We identified 1345 unique records, and 14 studies were included. Overall … Continue reading Effectiveness of #honey for symptomatic relief in upper #respiratory tract infections: a systematic review and meta-analysis

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Reducing #Antibiotic Prescribing in Primary Care for #Respiratory Illness

One-third of outpatient antibiotic prescriptions for pediatric acute respiratory tract infections (ARTIs) are inappropriate. We evaluated a distance learning program’s effectiveness for reducing outpatient antibiotic prescribing for ARTI visits.. In this stepped-wedge clinical trial run from November 2015 to June 2018, we randomly assigned 19 pediatric practices belonging to the Pediatric Research in Office Settings Network or the NorthShore University HealthSystem to 4 wedges. Visits … Continue reading Reducing #Antibiotic Prescribing in Primary Care for #Respiratory Illness

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Stress related disorders and subsequent risk of life threatening #infections: population based sibling controlled cohort study

..144 919 individuals with stress related disorders (post-traumatic stress disorder (PTSD), acute stress reaction, adjustment disorder, and other stress reactions) identified from 1987 to 2013 ..Stress related disorders were associated with all studied life threatening infections, with the highest relative risk observed for meningitis (sibling based analysis 1.63 (1.23 to 2.16)) and endocarditis (1.57 (1.08 to 2.30)). Younger age at diagnosis of a stress related disorder … Continue reading Stress related disorders and subsequent risk of life threatening #infections: population based sibling controlled cohort study

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