Category: supplements

Diet, Gastroenterology, Hepatology, supplements

Vitamin #D for treatment of non‐alcoholic #fatty liver disease detected by transient elastography: A randomized, double‐blind, placebo‐controlled trial

To evaluate the effects of vitamin D on transient elastography (TE, FibroScan) indices of liver steatosis (controlled attenuation parameter [CAP]) and fibrosis (liver stiffness measurement [LSM]) in adults with non‐alcoholic fatty liver disease (NAFLD).. ..Both CAP and LSM gradually decreased in vitamin D‐treated patients and slightly increased in the placebo arm. Vitamin D was superior to placebo for both primary outcomes (mean differences in CAP … Continue reading Vitamin #D for treatment of non‐alcoholic #fatty liver disease detected by transient elastography: A randomized, double‐blind, placebo‐controlled trial

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Psychiatry, supplements

Effect of Long-term Vitamin #D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant #Depressive Symptoms and on Change in Mood Scores A Randomized Clinical Trial

Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there have been few long-term, high-dose large-scale trials.. Randomized assignment in a 2 × 2 factorial design to vitamin D3 (2000 IU/d of cholecalciferol) and fish oil or placebo; 9181 were randomized to vitamin D3 and 9172 were randomized to matching placebo.. Among the 18 353 randomized participants (mean age, 67.5 … Continue reading Effect of Long-term Vitamin #D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant #Depressive Symptoms and on Change in Mood Scores A Randomized Clinical Trial

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Rheumatology, supplements

Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis

Patients with rheumatoid arthritis (RA) are at high risk for cardiovascular (CV) mortality, attributed to chronic inflammation coupled with elevated circulatory homocysteine levels. Increasing the serum folate level reduces homocysteine, but the association of serum folate concentration with CV mortality in patients with RA has not been previously examined.. A total of 683 patients with RA (mean [SE] age, 55.9 [1.0] years; 225 [30.2%] men; … Continue reading Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis

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Cardiology, Neurology, supplements

Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults

The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared with those with enalapril alone, but the lifetime stroke-free survival associated with the treatment is unknown.. ..Compared with enalapril alone, the enalapril plus folic acid treatment projected a mean lifetime stroke-free survival gain of 1.75 months, with an interquartile range … Continue reading Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults

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Oncology, supplements

#Curcumin and #Cancer

Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. The present review focuses on the cell signaling pathways involved in cancer development and proliferation, and which are targeted by curcumin. Curcumin has been reported to … Continue reading #Curcumin and #Cancer

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supplements

Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients

Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients.. ..A total of 1360 patients were found to be vitamin D–deficient during point-of-care screening and underwent randomization. Of these patients, 1078 had baseline vitamin D deficiency (25-hydroxyvitamin D level, <20 ng per milliliter [50 nmol per liter]) confirmed by subsequent testing and were included in the primary analysis … Continue reading Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients

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supplements

Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults

..(VITAL) tested vitamin D (2000 IU/day) and/or n-3 FA (1 g/day) supplementation in a 2 × 2 factorial design among women ≥55 and men ≥50 years of age. Baseline characteristics were well balanced. In the active arms, 25-OH vitamin D rose 39% and n-3 FA rose 55% vs minimal change in placebo arms. Neither supplement reduced biomarkers at 1 year. Vitamin D resulted in 8.2% … Continue reading Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults

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