Predicting language therapy outcomes in bilinguals with aphasia (BWA) remains challenging due to the multiple pre- and poststroke factors that determine the deficits and recovery of their two languages. Computational models that simulate language impairment and treatment outcomes in BWA can help predict therapy response and identify the optimal language for treatment. Here we used… Continue reading Predicting #language treatment response in bilingual #aphasia using neural network-based patient models
Category: Neurology
#Sleep difficulties, incident #dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study
Sleep difficulties have been implicated in the development and progression of dementia and in all-cause mortality. This study examines the relationship between sleep difficulties, incident dementia and all-cause mortality over 8 years of follow-up among a nationally representative sample of older (≥65 years) adults in the United States. We used data collected from the National… Continue reading #Sleep difficulties, incident #dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study
Randomized Manipulation of Early #Cognitive Experience Impacts Adult Brain Structure
Does early exposure to cognitive and linguistic stimulation impact brain structure? Or do genetic predispositions account for the co-occurrence of certain neuroanatomical phenotypes and a tendency to engage children in cognitively stimulating activities? Low socioeconomic status infants were randomized to either 5 years of cognitively and linguistically stimulating center-based care or a comparison condition. The… Continue reading Randomized Manipulation of Early #Cognitive Experience Impacts Adult Brain Structure
Causal Effect of #Tooth Loss on Functional Capacity in Older Adults in England: A Natural Experiment
Background/ObjectivesTooth loss is associated with reduced functional capacity, but so far, there is no relevant causal evidence reported. We investigated the causal effect of tooth loss on the instrumental activities of daily living (IADL) among older adults in England. DesignNatural experiment study with instrumental variable analysis. SettingThe English Longitudinal Study of Aging (ELSA) combined with… Continue reading Causal Effect of #Tooth Loss on Functional Capacity in Older Adults in England: A Natural Experiment
Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study
Patients with obsessive-compulsive disorder (OCD) tend to be comorbid with stroke-related risk factors, including obesity, hypertension, and diabetes. However, the temporal association between OCD and subsequent stroke risk is unclear. Methods:Using data collected between 2001 and 2010 by Taiwan’s National Health Insurance Research Database, 28 064 adult patients with OCD (International Classification of Diseases, Ninth… Continue reading Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study
The Effects of Chronic Exposure to Ambient #Traffic-Related Air #Pollution on #Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats
Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer’s disease (AD). Preclinical data corroborating this association are largely from studies of male animals exposed acutely or subchronically to high levels of isolated fractions of TRAP. What remains unclear is whether chronic exposure to ambient TRAP modifies AD risk and the influence of… Continue reading The Effects of Chronic Exposure to Ambient #Traffic-Related Air #Pollution on #Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats
Effects of #music participation for mild #cognitive impairment and #dementia: A systematic review and meta-analysis
To examine randomized controlled trials with active music-making interventions, in which older adults with probable mild cognitive impairment (MCI) or dementia physically participate in music, and their effects on cognitive functioning, emotional well-being, and social engagement. Participating in music-making is engaging and has shown diverse benefits. Additionally, this review categorized the music activities of each… Continue reading Effects of #music participation for mild #cognitive impairment and #dementia: A systematic review and meta-analysis
The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
To provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors. Data SourceWe conducted a systematic review and searched MEDLINE, EMBASE and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke. Study SelectionTitles,… Continue reading The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia
Discovery of mechanisms that underlie variable penetrance for neuropsychiatric illness in the context of genetic variants that carry elevated risk can advance novel treatment approaches for these disorders. Objective To test the hypothesis that mitochondrial compensation is associated with the variable penetrance of schizophrenia in the 22q11.2 deletion syndrome (22q11DS). Design, Setting, and Participants This… Continue reading Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia
