Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast differentiation and muscle glucose uptake, and VPS39 is downregulated in myoblasts… Continue reading VPS39-deficiency observed in type 2 #diabetes impairs #muscle stem cell differentiation via altered autophagy and epigenetics
Category: Neurology
#Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis
Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD). ObjectivesTo examine the association between neuroticism and risk of PD in a large cohort and a meta‐analysis of prospective cohort studies. MethodsParticipants from the UK Biobank (N = 490,755) completed a neuroticism scale in… Continue reading #Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis
Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study
To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the occurrence of PSE. Methods :A total of 1152 patients with newly diagnosed ischemic stroke admitted to our hospital from March to… Continue reading Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study
The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial
It is currently unknown whether exergaming is efficacious in people with major neurocognitive disorder (MNCD) residing in long-term care facilities. This pilot randomized controlled trial (RCT) explored the efficacy of a stepping exergame program on gait speed, balance, mobility, reaction time, cognitive and neuropsychiatric outcomes, quality of life, and daily life functioning in people with… Continue reading The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial
Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage
To determine whether obstructive sleep apnea (OSA) is associated with intracerebral hemorrhage (ICH) risk, we assessed premorbid OSA exposure of patients with nontraumatic ICH and matched controls. Methods: Ethnic/Racial Variations of Intracerebral Hemorrhage is a multicenter, case-control study evaluating risk factors for ICH that recruited 3000 cases with ICH and 3000 controls. OSA status was… Continue reading Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage
#Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review
This review aimed to summarize the evidence on the risk of thromboembolism associated with carotid and aortic atherosclerosis in patients with AF, and the potential impact of their inclusion in current stroke risk stratification scores. Methods MEDLINE, Web of Science and EMBASE were systematically searched to identify all published studies providing relevant data through 28… Continue reading #Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review
Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition
The purpose of this study was to clarify the association between self‐reported night sleep duration and cognitive functions such as word memory, story memory, attention, executive function, and processing speed of older adults with normal global cognitive function. Methods A total of 241 functionally independent older adults (mean age, 75.5 ± 6.4 years) participated in… Continue reading Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition
Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial
Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older… Continue reading Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial
Association of Type 2 #Diabetes Mellitus and Glycemic Control With Intracranial Plaque Characteristics in Patients With Acute Ischemic #Stroke
Type 2 diabetes mellitus (T2DM) has shown to be associated with carotid plaque vulnerability. However, the impact of T2DM on intracranial artery atherosclerosis is not well‐understood. Purpose To evaluate the association of diabetes and glycemic control with intracranial atherosclerotic plaque characteristics identified by three‐dimensional contrast enhanced MR vessel wall imaging in patients after acute ischemic… Continue reading Association of Type 2 #Diabetes Mellitus and Glycemic Control With Intracranial Plaque Characteristics in Patients With Acute Ischemic #Stroke
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