#Disruption of the blood−brain barrier in 22q11.2 deletion syndrome

Neuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia. As the blood−brain barrier is the immunological interface between the brain and the periphery, we investigated whether this vascular phenotype is intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome (22qDS). Blood−brain barrier like endothelium differentiated from human 22qDS+schizophrenia-induced pluripotent stem cells exhibited impaired barrier integrity, a phenotype substantiated in … Continue reading #Disruption of the blood−brain barrier in 22q11.2 deletion syndrome

Rate This

Increased Risk of #Parkinson’s Disease in Patients With #Schizophrenia Spectrum Disorders

PD comorbid with schizophrenia has been considered rare because these diseases associate with opposite alterations in the brain dopamine system. The objective of this study was to investigate the risk of PD after a diagnosis of a schizophrenia spectrum disorder. Methods Regionally, this was a retrospective record‐based case–control study. The cohort included 3045 PD patients treated 2004–2019 in southwestern Finland. Nationally this was a nested … Continue reading Increased Risk of #Parkinson’s Disease in Patients With #Schizophrenia Spectrum Disorders

Rate This

#ABCA13 dysfunction associated with #psychiatric disorders causes impaired cholesterol trafficking

ATP-binding cassette subfamily A member 13 (ABCA13) is predicted to be the largest ABC protein, consisting of 5,058 amino acids and a long N-terminal region. Mutations in the ABCA13 gene were reported to increase the susceptibility to schizophrenia, bipolar disorder and major depression. However, little is known about the molecular functions of ABCA13 or how they associate with psychiatric disorders. Here, we examined the biochemical … Continue reading #ABCA13 dysfunction associated with #psychiatric disorders causes impaired cholesterol trafficking

Rate This

Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care

Evaluate efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) with 1-day initiation during hospitalization for acute exacerbation of schizophrenia followed by transition to outpatient care.. The phase 3b double-blind Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness (ALPINE) study was conducted from November 2017 to March 2019. Adults with acute schizophrenia according to DSM-5 criteria were randomized (1:1) to AL (AL NanoCrystal Dispersion … Continue reading Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care

Rate This

Early- Versus Adult-Onset #Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training

Developmental stages characterized by greater neural plasticity might be critical periods during which the effects of cognitive training (CT) could theoretically be maximized. However, experiencing a first episode of schizophrenia during childhood or adolescence (ie, early-onset schizophrenia [EOS]) may reduce the brain’s ability to benefit from CT. This study examined the effects of EOS versus onset at > 18 years of age (ie, adult-onset schizophrenia … Continue reading Early- Versus Adult-Onset #Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training

Rate This

Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders A Genome-wide Association Study

People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases.. schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD) body mass index (BMI) ..Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD … Continue reading Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders A Genome-wide Association Study

Rate This

Evidence for causal effects of lifetime #smoking on risk for #depression and #schizophrenia: a Mendelian randomisation study

Smoking prevalence is higher amongst individuals with schizophrenia and depression compared with the general population. Mendelian randomisation (MR) can examine whether this association is causal using genetic variants identified in genome-wide association studies (GWAS). There was strong evidence to suggest smoking is a risk factor for both schizophrenia (odds ratio (OR) 2.27, 95% confidence interval (CI) 1.67–3.08, p < 0.001) and depression (OR 1.99, 95% … Continue reading Evidence for causal effects of lifetime #smoking on risk for #depression and #schizophrenia: a Mendelian randomisation study

Rate This