According to a commonly held view, the obesity pandemic is caused by overconsumption of modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary lifestyle. However, obesity rates remain at historic highs, despite a persistent focus on eating less and moving more, as guided by the energy balance model (EBM). This public health failure may… Continue reading The #carbohydrate-insulin model: a physiological perspective on the #obesity pandemic
Category: Endocrinology
Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high- #fat diet – implications for daily control of #satiety
Temporal partitioning of daily food intake is crucial for survival and involves the integration of internal circadian states and external influences such as the light-dark cycle and dietary composition. These intrinsic and extrinsic factors are interdependent with misalignment of circadian rhythms promoting body weight gain, while consumption of a calorie dense diet elevates the risk… Continue reading Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high- #fat diet – implications for daily control of #satiety
The Relationship Between Body #Mass Index and In-Hospital #Mortality in the Contemporary Era of an Acute Myocardial #Infarction Management
The association between body mass index (BMI) and clinical outcomes following an acute myocardial infarction (AMI) remains controversial. Our objective was to investigate the relationship between BMI and AMI presentation, in-hospital clinical course and mortality in the contemporary era of AMI management. Methods: Patients, hospitalized for an AMI between October 2015 and December 2016, were… Continue reading The Relationship Between Body #Mass Index and In-Hospital #Mortality in the Contemporary Era of an Acute Myocardial #Infarction Management
#Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
COVID-19 induces a robust, extended inflammatory “cytokine storm” that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a key innate immune cell population responsible for the cytokine storm that has been shown, in T2D, to promote excess inflammation in response to infection. Using peripheral monocytes and… Continue reading #Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
Association of #Cycling With All-Cause and #Cardiovascular Disease Mortality Among Persons With #DiabetesThe European Prospective Investigation Into Cancer and Nutrition (EPIC) Study
Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes. Objective To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality. Design,… Continue reading Association of #Cycling With All-Cause and #Cardiovascular Disease Mortality Among Persons With #DiabetesThe European Prospective Investigation Into Cancer and Nutrition (EPIC) Study
Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures
We aimed to validate the association of genome-wide association study (GWAS)-identified loci and polygenic risk score with serum thyroid-stimulating hormone (TSH) concentrations and the diagnosis of hypothyroidism. Then, the causal relationship between serum TSH and osteoporotic bone fracture risk was tested. Methods: A cross-sectional study was done among patients of European Caucasian ethnicity recruited in… Continue reading Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures
Daily #energy expenditure through the human life course
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95… Continue reading Daily #energy expenditure through the human life course
Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
To examine whether glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) are preferentially initiated among patients with cardiovascular disease, heart failure (HF), or nephropathy, where these drug classes have established benefit, compared with dipeptidyl peptidase 4 inhibitors (DPP-4i), for which corresponding benefits have not been demonstrated. RESEARCH DESIGN AND METHODS We… Continue reading Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
Extrapolating Long-term Event-Free and Overall Survival With #Dapagliflozin in Patients With #Heart Failure and Reduced #Ejection Fraction
Sodium glucose cotransporter 2 inhibitors reduce morbidity and mortality in patients with heart failure and reduced ejection fraction (HFrEF). Clinicians may find estimates of the projected long-term benefits of sodium glucose cotransporter 2 inhibitors a helpful addition to clinical trial results when communicating the benefits of this class of drug to patients. Objective To estimate… Continue reading Extrapolating Long-term Event-Free and Overall Survival With #Dapagliflozin in Patients With #Heart Failure and Reduced #Ejection Fraction
