Background: The cardiovascular-kidney-metabolic (CKM) framework emphasizes the interplay of metabolic, renal, and cardiovascular abnormalities in cardiovascular disease risk. We aimed to develop a CKM syndrome age algorithm using routinely collected health checkup and claims data in Japan.Methods and results: We conducted a cohort study of 376,612 men and 478,853 women aged 20-79 years in the… Continue reading Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data – Large-Scale Epidemiological Study
Tag: Kidney
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease
Background: Evidence on the effects of 12-week telehealth-supported home-based exercise in advanced non-dialysis chronic kidney disease (CKD) remains limited. This study evaluated its effects on functional capacity, sarcopenia risk, and patient-reported outcomes in patients with stage 4-5 CKD.Methods: In this prospective, parallel-group randomized controlled trial (October 2024-July 2025), 54 non-dialysis patients aged ≥45 years with… Continue reading Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease
Acute Phosphate Nephropathy Following Oral Sodium Phosphate Bowel Preparation
Acute phosphate nephropathy (APN) is a rare but important cause of acute kidney injury (AKI), most commonly associated with the use of oral sodium phosphate bowel preparations administered prior to colonoscopy. In this report, we describe the case of a 60-year-old female patient who developed severe AKI necessitating temporary hemodialysis after bowel preparation with a… Continue reading Acute Phosphate Nephropathy Following Oral Sodium Phosphate Bowel Preparation
Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
Introduction: When a patient's presentation raises suspicions for conditions other than diabetic kidney disease (DKD), such as sudden onset proteinuria <5 years after the onset of type 2 diabetes, proteinuria without retinopathy or neuropathy, acute kidney injury, active urinary sediment, or hematuria, clinically indicated kidney biopsies are typically carried out. Consequently, a high incidence of… Continue reading Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
Aims/hypothesis: Blood #pressure variability (BPV) is a risk factor for #kidney disease progression in hypertension and type 2 diabetes; however, the role of BPV in kidney disease in type 1 diabetes is unknown. The aim of this study was therefore to determine whether BPV has an impact on kidney disease progression in an ethnically diverse… Continue reading The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
Kidney function and all-cause mortality in the oldest-old population: a three-cohort longitudinal study
With increasing global life expectancy, the prognostic significance of #kidney function in centenarians and supercentenarians should be clarified. The conventional estimated glomerular filtration rate ( #eGFR ) threshold of < 60 mL/min/1.73 m2 may not accurately reflect chronic kidney disease (CKD) in this population, highlighting the need for age-adapted definitions. This study investigated the association… Continue reading Kidney function and all-cause mortality in the oldest-old population: a three-cohort longitudinal study
Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Chronic kidney disease (CKD) is a devastating progressive condition accompanied with high morbidity and mortality rates. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have recently proven their renoprotective effects, whereas evidence for metformin remains limited but suggestive of potential benefit. This study aimed at comparing the efficacy and safety of metformin versus empagliflozin, a SGLT2 inhibitor, on retarding… Continue reading Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Effects of #finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 #diabetes and chronic #kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
Background: The mechanisms underlying cardiorenal benefits of finerenone remain unclear. This mechanistic trial aimed to evaluate the effects of finerenone on vascular stiffness, as assessed using the cardio-ankle vascular index (CAVI), and cardiorenal biomarkers in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD).Methods: Eligible patients with T2D and CKD (estimated glomerular filtration… Continue reading Effects of #finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 #diabetes and chronic #kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
The pathogenesis of Lewy body diseases (LBDs), including Parkinson’s disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in… Continue reading Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
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