Hepatic Lipoprotein Export and Remission of Human Type 2 #Diabetes after #Weight Loss

..Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase response by 24 … Continue reading Hepatic Lipoprotein Export and Remission of Human Type 2 #Diabetes after #Weight Loss

Sustained #weight loss and risk of #breast cancer in women ≥50 years: a pooled analysis of prospective data

..Compared with women with stable weight (± 2kg), women with sustained weight loss had a lower risk of breast cancer. This risk reduction was linear and specific to women not using postmenopausal hormones (>2-4.5kg lost: Hazard Ratio (HR)= 0.82, 95% confidence interval (CI): 0.70-0.96; >4.5-<9kg lost: HR = 0.75, 95% CI: 0.63-0.90; ≥9kg lost: HR = 0.68, 95% CI: 0.50-0.93). Women who lost ≥9kg and gained some (but not … Continue reading Sustained #weight loss and risk of #breast cancer in women ≥50 years: a pooled analysis of prospective data

Trends in Self-perceived #Weight Status, Weight Loss Attempts, and Weight Loss Strategies Among Adults in the United States, 1999-2006

..Increasing trends were observed in current measured BMI (difference, 1.20; 95% CI, 0.92-1.47; P for trend < .001), current measured weight (difference 2.77 kg; 95% CI, 1.92-3.61 kg; P for trend < .001), adjusted, self-reported, prior-year weight (difference, 2.36 kg; 95% CI, 1.52-3.21 kg; P for trend < .001), and the difference between measured and adjusted self-reported weight (difference 0.70 kg; 95% CI, 0.34-1.07 kg; P for trend < .001). During this period, … Continue reading Trends in Self-perceived #Weight Status, Weight Loss Attempts, and Weight Loss Strategies Among Adults in the United States, 1999-2006

Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study

..Compared with participants who remained at normal weight, those moving from the non-obese to obese category between young and middle adulthood had a 22% (hazard ratio 1.22, 95% confidence interval 1.11 to 1.33) and 49% (1.49, 1.21 to 1.83) higher risk of all cause mortality and heart disease mortality, respectively. Changing from obese to non-obese body mass index over this period was not significantly associated … Continue reading Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study