The group with epilepsy included in this study had a lower proportion of individuals with overweight and obesity than the general population (23.1% versus 42%) in 2015. However, the proportion of patients with obesity in the groups with DRE was significantly higher than that in the general population (17.9% versus 7.1%).•The J-shaped relationship between BMI… Continue reading Associations of #overweight and #obesity with drug-resistant #epilepsy
Category: Endocrinology
Influence of Free #Fatty Acid Concentrations and #Weight Loss on Adipose Tissue Direct Free Fatty Acid Storage Rates
The factors that determine the recycling of free fatty acids (FFA) back into different adipose tissue depots via the direct storage pathway are not completely understood. ObjectiveTo assess the interactions between adipocyte factors and plasma FFA concentrations that determine regional FFA storage rates. DesignWe measured direct adipose tissue FFA storage rates before and after weight… Continue reading Influence of Free #Fatty Acid Concentrations and #Weight Loss on Adipose Tissue Direct Free Fatty Acid Storage Rates
#Metabolic responses to polychromatic #LED and #OLED light at night
Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the effects of polychromatic white light using conventional light-emitting diodes (LED) and an alternative light source, organic light-emitting diodes (OLED), producing reduced spectral content in the short wavelength of blue… Continue reading #Metabolic responses to polychromatic #LED and #OLED light at night
Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnostic tools to predict NAFLD in prior studies. ObjectiveWe aimed to assess a newly validated method to measure intact molecules of insulin by mass spectrometry to predict NAFLD. MethodsPatients underwent… Continue reading Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
#Time-restricted feeding protects the blood #pressure circadian rhythm in #diabetic mice
The quantity and quality of food intake have been considered crucial for peoples' wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes… Continue reading #Time-restricted feeding protects the blood #pressure circadian rhythm in #diabetic mice
A critical role of hepatic #GABA in the metabolic dysfunction and #hyperphagia of #obesity
Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production in obesity-induced metabolic and energy dysregulation, we treated mice with two pharmacologic GABA-T inhibitors and knocked… Continue reading A critical role of hepatic #GABA in the metabolic dysfunction and #hyperphagia of #obesity
A Systematic Review of Dietary #Supplements and Alternative Therapies for #Weight Loss
Dietary supplements and alternative therapies are commercialized as a panacea for obesity/weight gain as a result of the minimal regulatory requirements in demonstrating efficacy. These products may indirectly undermine the value of guideline-driven obesity treatments. Included in this study is a systematic review of the literature of purported dietary supplements and alternative therapies for weight… Continue reading A Systematic Review of Dietary #Supplements and Alternative Therapies for #Weight Loss
Acute and long-term disruption of #glycometabolic control after #SARS-CoV-2 infection
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute respiratory syndrome coronavirus 2 infection may precipitate the onset of metabolic alterations by affecting glucose homeostasis. Here we describe abnormalities in glycometabolic control, insulin resistance and beta cell function in patients with… Continue reading Acute and long-term disruption of #glycometabolic control after #SARS-CoV-2 infection
Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in type 2 diabetic patients. Methods: Included studies were searched from Pubmed, Embase, and the Cochrane Library before July 2020. We synthesized the pooled results of the above… Continue reading Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
