Parkinson’s disease (PD) is a neurodegenerative disease that has a fast progression of motor dysfunction within the first 5 years of diagnosis, showing an annual motor rate of decline of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) between 5.2 and 8.9 points. We aimed to determine both motor and non-motor PD symptom… Continue reading #Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory #Dance Learning over 3-Years: A Preliminary Longitudinal Investigation
Author: aledopress
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Deaths in Children and #Young People in England following #SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting data
This is a preprint. It has not completed peer review. Background Deaths in children and young people (CYP) following SARS-CoV-2 infection are rare. Quantifying the risk of mortality is challenging because of high relative prevalence of asymptomatic and non-specific disease manifestations. Therefore, it is important to differentiate between CYP who have died of SARS-CoV-2 and… Continue reading Deaths in Children and #Young People in England following #SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting data
Auto-immune #hepatitis following #COVID vaccination
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH)… Continue reading Auto-immune #hepatitis following #COVID vaccination
Gut #microbiome heritability is nearly universal but environmentally contingent
Baboons inform on human gut microbiotaCommensal bacteria are found throughout an organism, but it is not known whether associations between gut bacteria and their host are heritable. Grieneisen et al. examined changes in the microbiomes of 585 wild baboons from fecal samples collected over 14 years (see the Perspective by Cortes-Ortiz and Amato). Almost all… Continue reading Gut #microbiome heritability is nearly universal but environmentally contingent
SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
Since the late 1980s, global antibiotic consumption and colorectal cancer (CRC) rates in those aged less than 50 years have soared. As the gut microbiome modulates many human processes, significantly altering microbiome structure and diversity with antibiotic therapy has previously been shown to influence CRC genesis in older adults. To our knowledge, no study before… Continue reading SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
Dose-Response Meta-Analysis on #Tooth Loss With the Risk of #Cognitive Impairment and #Dementia
To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia. DesignLongitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 databases through March 1, 2020. The study adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Risk estimates were… Continue reading Dose-Response Meta-Analysis on #Tooth Loss With the Risk of #Cognitive Impairment and #Dementia
#Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Psilocybin ameliorates stress-related behavioral deficit in mice•Psilocybin increases spine density and spine size in frontal cortical pyramidal cells•Psilocybin-evoked structural remodeling is persistent for at least 1 month•The dendritic rewiring is accompanied by elevated excitatory neurotransmission SummaryPsilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural… Continue reading #Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
The effect of #depression status change on daily #cigarette smoking amount according to sex: an eleven-year follow up study of the Korea Welfare Panel Study
In the past decade, the Korean smoking rate has only decreased by 3%, despite several smoking control policies. There is a need for such policies to take smokers’ psychological characteristics into account. Depression is a well-known contributor to failed smoking cessation. This study aimed to examine the effect of smokers’ depression status changes on their… Continue reading The effect of #depression status change on daily #cigarette smoking amount according to sex: an eleven-year follow up study of the Korea Welfare Panel Study
#Social Health and #Cardiovascular Disease Risk Factors: A cross-sectional study in a healthy older adult population
Poor social health is a risk factor for cardiovascular disease (CVD), however an in-depth exploration of the link through CVD risk factors is lacking. AimTo examine the relationship between social health (social isolation, social support, loneliness) and CVD risk factors among healthy older women and men. MethodsData were from 11,498 healthy community-dwelling Australians aged ≥70… Continue reading #Social Health and #Cardiovascular Disease Risk Factors: A cross-sectional study in a healthy older adult population
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