COVID-19 induces a robust, extended inflammatory “cytokine storm” that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a key innate immune cell population responsible for the cytokine storm that has been shown, in T2D, to promote excess inflammation in response to infection. Using peripheral monocytes and… Continue reading #Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
Tag: Diabetes
Association of #Cycling With All-Cause and #Cardiovascular Disease Mortality Among Persons With #DiabetesThe European Prospective Investigation Into Cancer and Nutrition (EPIC) Study
Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes. Objective To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality. Design,… Continue reading Association of #Cycling With All-Cause and #Cardiovascular Disease Mortality Among Persons With #DiabetesThe European Prospective Investigation Into Cancer and Nutrition (EPIC) Study
Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
To examine whether glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) are preferentially initiated among patients with cardiovascular disease, heart failure (HF), or nephropathy, where these drug classes have established benefit, compared with dipeptidyl peptidase 4 inhibitors (DPP-4i), for which corresponding benefits have not been demonstrated. RESEARCH DESIGN AND METHODS We… Continue reading Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
Extrapolating Long-term Event-Free and Overall Survival With #Dapagliflozin in Patients With #Heart Failure and Reduced #Ejection Fraction
Sodium glucose cotransporter 2 inhibitors reduce morbidity and mortality in patients with heart failure and reduced ejection fraction (HFrEF). Clinicians may find estimates of the projected long-term benefits of sodium glucose cotransporter 2 inhibitors a helpful addition to clinical trial results when communicating the benefits of this class of drug to patients. Objective To estimate… Continue reading Extrapolating Long-term Event-Free and Overall Survival With #Dapagliflozin in Patients With #Heart Failure and Reduced #Ejection Fraction
#Time-restricted feeding protects the blood #pressure circadian rhythm in #diabetic mice
The quantity and quality of food intake have been considered crucial for peoples' wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes… Continue reading #Time-restricted feeding protects the blood #pressure circadian rhythm in #diabetic mice
Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in type 2 diabetic patients. Methods: Included studies were searched from Pubmed, Embase, and the Cochrane Library before July 2020. We synthesized the pooled results of the above… Continue reading Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
We aimed to examine the number of teeth and masticatory function as oral health indices and clarify their roles in the pathogenesis of sarcopenia and diabetes mellitus in community-dwelling older adults. Subjects and methodsThis cross-sectional study was conducted with 635 older adults in Ohnan, Shimane Prefecture, in rural Japan. The number of teeth and masticatory… Continue reading Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
Associations Between #Fruit Intake and Risk of #Diabetes in the AusDiab Cohort
Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection. ObjectiveThe aims of this work were to examine associations between intake of fruit types and 1) measures of glucose tolerance and insulin sensitivity and 2) diabetes at follow-up.… Continue reading Associations Between #Fruit Intake and Risk of #Diabetes in the AusDiab Cohort
#Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
Our aim was to evaluate the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabetes. MethodsPost hoc analysis of changes in BP, antihypertensive medication prescriptions and symptoms during the initial total diet replacement phase was performed in… Continue reading #Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
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