Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40–70 years. FG was measured during 59,565 morning windows of 8,315 individuals (7.16 ± 3.17 days per participant). Mean FG was 96.2 ± 12.87 mg dl−1, rising by 0.234 mg dl−1 per year with… Continue reading Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
Globaplastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals… Continue reading In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
#Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower #Respiratory Tract Infection
BackgroundAntibiotic use remains common for the treatment of lower respiratory tract infections. The objective of this study was to evaluate the impact of antibiotic use on the duration and severity of acute lower respiratory tract infection (LRTI).ParticipantsAdult patients presenting to US primary or urgent care sites with a chief complaint of cough and symptoms consistent… Continue reading #Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower #Respiratory Tract Infection
#Beta-Blockers after Myocardial #Infarction and Preserved #Ejection Fraction
BACKGROUNDMost trials that have shown a benefit of beta-blocker treatment after myocardial infarction included patients with large myocardial infarctions and were conducted in an era before modern biomarker-based diagnosis of myocardial infarction and treatment with percutaneous coronary intervention, antithrombotic agents, high-intensity statins, and renin–angiotensin–aldosterone system antagonists.METHODSIn a parallel-group, open-label trial performed at 45 centers in… Continue reading #Beta-Blockers after Myocardial #Infarction and Preserved #Ejection Fraction
Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Dysregulation of the gut microbiome has been implicated in Parkinson's disease (PD). This study aimed to evaluate the clinical effects and safety of a single faecal microbiota transplantation (FMT) in patients with early-stage PD.MethodsThe GUT-PARFECT trial, a single-centre randomised, double-blind, placebo-controlled trial was conducted at Ghent University Hospital between December 01, 2020 and December 12,… Continue reading Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Cognitive decline in people experiencing homelessness is an increasingly recognised issue. We compared the prevalence of dementia among people experiencing homelessness to housed individuals in the general population and those living in low-income neighbourhoods.MethodsWe conducted a population-based, cross-sectional, comparative analysis using linked health-care administrative data from Ontario, Canada. We included individuals aged 45 years or… Continue reading Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied… Continue reading Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
#Virtual reality for #pain management in hospitalized patients with #cancer: A randomized controlled trial
Hospitalized patients with cancer often experience acute and/or chronic pain. Although virtual reality (VR) has been extensively studied across a wide range of clinical settings, no studies have yet evaluated potential impact on pain management in this patient population.MethodsProspective randomized controlled trial at an urban academic hospital comparing VR against an active control to mitigate… Continue reading #Virtual reality for #pain management in hospitalized patients with #cancer: A randomized controlled trial
Impact of #Mental Health Treatment on Outcomes in Patients With #Heart Failure and Ischemic Heart Disease
BackgroundThere is conflicting evidence as to the impact of mental health treatment on outcomes in patients with heart disease. The aim of this study was to examine whether individuals who received mental health treatment for anxiety or depression after being hospitalized for ischemic disorders or heart failure had a reduced frequency of rehospitalizations, emergency department… Continue reading Impact of #Mental Health Treatment on Outcomes in Patients With #Heart Failure and Ischemic Heart Disease
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