Background: Metabolic and bariatric surgery (MBS) is an effective treatment for severe obesity, yet postoperative weight loss outcomes vary considerably between patients. With the relevance of the gut microbiome for obesity, it is of interest to understand the potential role of the oral and gut microbiota for the outcome of MBS. This pilot, hypothesis-generating study… Continue reading Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Tag: microbiota
Encapsulated faecal microbiota transfer to target immune activation in patients with cirrhosis and ascites (TransImmune): protocol for a randomised, double-blind, Phase IIa, placebo-controlled trial
Introduction: Bacterial translocation and gut dysbiosis are key drivers of systemic immune activation in decompensated cirrhosis, precipitating inflammatory complications such as acute-on-chronic liver failure (ACLF). Currently, no licensed therapies effectively restore intestinal barrier function or reverse dysbiosis in this vulnerable population. While previous studies have suggested benefits of faecal microbiota transfer (FMT) in hepatic encephalopathy… Continue reading Encapsulated faecal microbiota transfer to target immune activation in patients with cirrhosis and ascites (TransImmune): protocol for a randomised, double-blind, Phase IIa, placebo-controlled trial
Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Background: REBYOTA and VOWST are the first FDA-approved live biotherapeutic products (LBPs) for recurrent Clostridioides difficile infection (rCDI). Prior FDA safety alerts (2019-2020) regarding invasive infections from investigational fecal microbiota transplantation underscore the need for post-marketing surveillance of these novel products.Aims: To characterize the real-world safety profiles of REBYOTA and VOWST using the FDA Adverse… Continue reading Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Dietary index for gut microbiota (DI-GM) and irritable bowel syndrome: a case-control study
This study investigated whether the Dietary Index for Gut #Microbiota (DI-GM), a measure of diet quality for gut health, is associated with #IBS risk, and symptom severity, inflammation. A case-control study included 350 adults (175 IBS patients per Rome IV and 175 matched controls). Dietary intake was assessed using a validated food frequency questionnaire to… Continue reading Dietary index for gut microbiota (DI-GM) and irritable bowel syndrome: a case-control study
#Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36) acupoints in alleviating depressive symptoms and elucidates the underlying mechanisms.MethodsSixty male C57BL/6J mice were subjected to an 8-week chronic unpredictable mild stress (CUMS) paradigm. Acupuncture was administered to two groups during the final 3 weeks: one under CUMS and the other without… Continue reading #Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
Consumption of trimethylamine N‐oxide (TMAO) precursors, such as carnitine found in lean beef, raises circulating TMAO concentrations; however, a healthy dietary pattern may attenuate these effects.MethodsThis randomized, 4‐period crossover, controlled‐feeding study investigated the effects of Mediterranean‐style (MED) diets (carbohydrate 42%, protein 17%, fat 41%) with 14 (MED0.5; 0.5 oz), 71 (MED2.5; 2.5 oz), and 156… Continue reading Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
Editor’s summaryThe gut #microbiota has long been an aspirational target for clinical delivery of therapeutics. Successful therapy by this route depends on ensuring engraftment of the therapeutic organisms and their clearance after treatment. Whitaker et al. have engineered a strain of Bacteroides vulgatus, which is commonly found in the gut of healthy humans, with two… Continue reading Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
Social #anxiety disorder-associated gut #microbiota increases #social #fear
Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice that received SAD patient microbiota had a specific heightened sensitivity to social fear without affecting other… Continue reading Social #anxiety disorder-associated gut #microbiota increases #social #fear
Atypical #gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice
Gut bacterial ecosystem is linked to host’s exercise capacity independent of food habits• Despite reduced bacterial diversity, endurance athletes exhibit higher fecal SCFA levels• Gut microbiota from athletes improves insulin sensitivity of transplanted mice• The gut bacterial ecosystem might be driven by access to energy resources left by the hostSummaryAlthough the gut microbiota is known… Continue reading Atypical #gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice
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