Metastasis is the spread of cancer cells from primary tumours to distant organs and is the cause of 90% of cancer deaths globally1,2. Metastasizing cancer cells are uniquely vulnerable to immune attack, as they are initially deprived of the immunosuppressive microenvironment found within established tumours3. There is interest in therapeutically exploiting this immune vulnerability to… Continue reading #Aspirin prevents #metastasis by limiting platelet TXA2 suppression of T cell #immunity
Impact of different types of physical #exercise on sleep quality in older population with #insomnia: a systematic review and network meta-analysis of randomised controlled trials
Objective To measure the impact of each type of exercise on sleep quality and identify the exercise that enhances sleep quality the most.Study selection Eligible randomised controlled trials that compare physical exercise to routine activities, usual care, non-physical activity, or health education to measure the Pittsburgh Sleep Quality Index.Data source Studies retrieved from Medline, Embase,… Continue reading Impact of different types of physical #exercise on sleep quality in older population with #insomnia: a systematic review and network meta-analysis of randomised controlled trials
Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Background:Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential antidepressant effects, population studies yield inconsistent results. Objective:To compare the risk for depression in older adults with type 2 diabetes (T2D) initiating treatment with GLP-1RAs versus sodium–glucose cotransporter-2 inhibitors (SGLT2is) or dipeptidyl peptidase-4 inhibitors (DPP4is).Design:Target trial emulation study.Setting:U.S. National Medicare administrative data from January 2014 to… Continue reading Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
#Dairy Consumption and the Colonic Mucosa-Associated Gut #Microbiota in Humans—A Preliminary Investigation
Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota. Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals… Continue reading #Dairy Consumption and the Colonic Mucosa-Associated Gut #Microbiota in Humans—A Preliminary Investigation
Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Objective To address the comparative effectiveness of common interventional procedures for chronic non-cancer (axial or radicular) spine pain.Design Systematic review and network meta-analysis (NMA) of randomised controlled trials (RCTs).Data sources Medline, Embase, CINAHL, CENTRAL, and Web of Science from inception to 24 January 2023.Study selection RCTs that enrolled patients with chronic non-cancer spine pain, randomised… Continue reading Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Integrating the #environmental and genetic architectures of #aging and mortality
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. To systematically identify environmental exposures associated with aging in the UK Biobank, we first conducted an exposome-wide analysis… Continue reading Integrating the #environmental and genetic architectures of #aging and mortality
Effect of #broccoli sprout extract and baseline gut microbiota on fasting blood #glucose in #prediabetes: a randomized, placebo-controlled trial
More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an isothiocyanate that reduces hepatic gluconeogenesis in individuals with type 2 diabetes and is well tolerated when provided as a broccoli sprout extract (BSE). Here we report a randomized, double-blind, placebo-controlled trial in which drug-naive individuals with prediabetes… Continue reading Effect of #broccoli sprout extract and baseline gut microbiota on fasting blood #glucose in #prediabetes: a randomized, placebo-controlled trial
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
BackgroundFruit- and vegetable-rich diets may protect against metabolic syndrome (MetS), partly due to their high polyphenol content.ObjectivesThis study examined the association between dietary polyphenol intake, MetS risk, and cardiometabolic factors in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsA total of 6387 participants (mean age 49.8 y, 65% female) were included. Food intake was assessed… Continue reading Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
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