Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients.. ..A total of 1360 patients were found to be vitamin D–deficient during point-of-care screening and underwent randomization. Of these patients, 1078 had baseline vitamin D deficiency (25-hydroxyvitamin D level, <20 ng per milliliter [50 nmol per liter]) confirmed… Continue reading Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients
#Chili Pepper Consumption and Mortality in Italian Adults
..Over a median follow-up of 8.2 years, a total of 1,236 deaths were ascertained. Multivariable hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality among participants in the regular (>4 times/week) relative to none/rare intake were 0.77 (95% confidence interval [CI]: 0.66 to 0.90) and 0.66 (95% CI: 0.50 to 0.86), respectively. Regular intake… Continue reading #Chili Pepper Consumption and Mortality in Italian Adults
#Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort
Ultraprocessed foods (UPF) are widespread in Western diets.. ..Absolute T2D rates in the lowest and highest UPF consumers were 113 and 166 per 100 000 person-years, respectively. Consumption of UPF was associated with a higher risk of T2D (multi-adjusted hazard ratio [HR] for an absolute increment of 10 in the percentage of UPF in the diet,… Continue reading #Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort
#THROMBOEMBOLIC RISK IN MEDICAL PATIENT: AN EXTENSIVE REVIEW AND FUTURE PERSPECTIVES
..Many studies have proven relevant reduction of fatal pulmonary embolism due to improved medical practice aimed to provide proper thromboembolic prophylactic therapy. RESULTS: Despite scientific efforts in clinical prevention, influence of some patients demographic variables are often underestimated (i.e. older age..) and real burden of absolute venous thromboembolic risk and thromboprophylactic efficacy remain unclear. Moreover,… Continue reading #THROMBOEMBOLIC RISK IN MEDICAL PATIENT: AN EXTENSIVE REVIEW AND FUTURE PERSPECTIVES
Oseltamivir plus usual care versus usual care for #influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial
Antivirals are infrequently prescribed in European primary care for influenza-like illness, mostly because of perceived ineffectiveness in real world primary care and because individuals who will especially benefit have not been identified in independent trials.. ..The estimated absolute mean benefit from oseltamivir was 1·02 days (95% [BCrI] 0·74–1·31) overall, and in the prespecified subgroups, ranged… Continue reading Oseltamivir plus usual care versus usual care for #influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial
Boom Chack Boom—A multimethod investigation of motor inhibition in professional #drummers
Our hands are the primary means for motor interaction with the environment, and their neural organization is fundamentally asymmetric: While most individuals can perform easy motor tasks with two hands equally well, only very few individuals can perform complex fine motor tasks with both hands at a similar level of performance.. ..Our results show that… Continue reading Boom Chack Boom—A multimethod investigation of motor inhibition in professional #drummers
Acute #Kidney Injury Among Older Patients Undergoing Coronary #Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
..Comorbid diseases and aging-related conditions were both more common among individuals experiencing acute kidney injury. However, after multivariable adjustment, no aging-related conditions were retained. There were 11 risk factors in the final model; the strongest were heart failure on presentation (odds ratio [OR] 1.91; 95% confidence interval [CI], 1.41-2.59), body mass index [BMI] >30 (vs… Continue reading Acute #Kidney Injury Among Older Patients Undergoing Coronary #Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
#Mindfulness-Based Blood #Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial
..A priori selected primary self-regulation outcomes showed improvements at one-year follow-up vs. baseline, including attention control (Sustained Attention to Response Task correct no-go score, p<0.001), emotion regulation (Difficulties in Emotion Regulation Score, p = 0.02), and self-awareness (Multidimensional Assessment of Interoceptive Awareness, p<0.001). Several determinants of hypertension were improved in participants not adhering to American… Continue reading #Mindfulness-Based Blood #Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial
Efficacy and tolerability of #duloxetine in patients with knee #osteoarthritis: a meta‐analysis of randomised controlled trials
..Duloxetine achieved significant reductions in primary outcomes including Brief Pain Inventory 24‐h average pain score (weighted mean difference (WMD) = −0.74, 95% confidence interval (CI) = −0.92 to −0.57), weekly mean of the 24‐h average pain score (WMD = −0.76, 95% CI = −0.96 to −0.56), WOMAC stiffness score (WMD = −0.47, 95% CI =… Continue reading Efficacy and tolerability of #duloxetine in patients with knee #osteoarthritis: a meta‐analysis of randomised controlled trials
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