..The 114 patients who reported indoor tanning exposure were younger at diagnosis than the 222 patients who did not (51.5 vs 64.0 years, two-sided P < .001). BRAF V600E genotype was more prevalent in ever-users than in nonusers (42.9% vs 28.3%, two-sided P = .04) and higher in ever-users who initiated indoor tanning prior to age… Continue reading Association of Indoor #Tanning Exposure With Age at #Melanoma Diagnosis and BRAF V600E Mutations
Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study
... According to the criteria, 57% (52% to 62%) of the 130.5 million prescriptions were for appropriate indications, 25% (21% to 29%) were inappropriate, and 18% (15% to 22%) had no documented indication. This corresponds to an estimated 24 million prescriptions without a documented indication. Being an adult male, spending more time with the provider,… Continue reading Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study
Use of #anastrozole for #breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial
..3864 women were recruited between Feb 2, 2003, and Jan 31, 2012. 1920 women were randomly assigned to 5 years anastrozole and 1944 to placebo. After a median follow-up of 131 months (IQR 105–156), a 49% reduction in breast cancer was observed for anastrozole (85 vs 165 cases, hazard ratio [HR] 0·51, 95% CI 0·39–0·66,… Continue reading Use of #anastrozole for #breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial
Wellbeing in #Brass Bands: The Benefits and Challenges of Group #Music Making
..As well as replicating the majority of the physical, psychological and social wellbeing benefits of choral music making in our brass band sample, we sought to provide a balanced view of impacts by inviting participants to discuss the challenges as well as the positives of making music in a group.. ..Conclusion This paper has revealed… Continue reading Wellbeing in #Brass Bands: The Benefits and Challenges of Group #Music Making
#Sleep duration, midday napping, and sleep quality and incident #stroke The Dongfeng-Tongji cohort
..Compared with sleeping 7 to <8 hours/night, those reporting longer sleep duration (≥9 hours/night) had a greater risk of total stroke (hazard ratio [HR] 1.23; 95% confidence interval [CI] 1.07–1.41), while shorter sleep (<6 hours/night) had no significant effect on stroke risk. The HR (95% CI) of total stroke was 1.25 (1.03–1.53) for midday napping… Continue reading #Sleep duration, midday napping, and sleep quality and incident #stroke The Dongfeng-Tongji cohort
Low‐Dose #Aspirin for Primary Prevention of #Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study
..Over a median follow‐up of 11.3 years, low‐dose aspirin use was associated with a trend toward decreased risk of ischemic cardiac death in white participants (adjusted hazard ratio: 0.86; 95% CI, 0.68–1.10), especially in women (adjusted hazard ratio: 0.72; 95% CI, 0.51–1.02), but not in black participants (adjusted hazard ratio: 1.18; 95% CI, 0.98–1.40). Similar… Continue reading Low‐Dose #Aspirin for Primary Prevention of #Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study
Associations between Skeletal #Muscle and #Myocardium in Aging: A Syndrome of “Cardio‐Sarcopenia”?
..We hypothesize that among aging adults with sarcopenia, alterations in myocardial structure and/or function may exist, resulting in a syndrome of “cardio‐sarcopenia.” ..Participants with sarcopenia had smaller left ventricular (LV) sizes (lower LV internal diameter end diastole (4.1 ± .7 vs 4.5 ± .6 cm; P < .0001), lower LV internal diameter end systole (2.3 ± .5 vs 2.5 ± .4 cm; P = .010),… Continue reading Associations between Skeletal #Muscle and #Myocardium in Aging: A Syndrome of “Cardio‐Sarcopenia”?
Influence of #sleep problems and co-occurring musculoskeletal pain on long-term prognosis of chronic low #backpain: the HUNT Study
Compared with persons without sleeplessness, persons who often/always experienced sleeplessness had a lower probability of recovery from chronic LBP (RR 0.65, 95% CI 0.57 to 0.74 in women and RR 0.81, 95% CI 0.69 to 0.95 in men). Although there was no clear evidence of statistical interaction between sleeplessness and co-occurring musculoskeletal pain, women and men who… Continue reading Influence of #sleep problems and co-occurring musculoskeletal pain on long-term prognosis of chronic low #backpain: the HUNT Study
Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers
..In adjusted analysis, a 5-ppb (parts per billion) increase in ozone concentration was associated with a greater percentage of emphysema (β = 0.94; 95% CI, 0.25-1.64; P = .007) and percentage of air trapping (β = 1.60; 95% CI, 0.16-3.04; P = .03); worse scores for the mMRC Dyspnea Scale (β = 0.10; 95% CI, 0.03-0.17; P = .008), CAT (β = 0.65; 95% CI, 0.05-1.26; P = .04), and SGRQ… Continue reading Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers
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