Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Hypoglycemia induced by direct-acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life-threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety signal for DAAs. MethodsReports to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from 1 …

Continue reading Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Development of a #hypoglycaemia risk score to identify high‐risk individuals with advanced type 2 diabetes in DEVOTE

The ability to differentiate patient populations with type 2 diabetes at high risk of severe hypoglycaemia could impact clinical decision making. The aim of this study was to develop a risk score, using patient characteristics, that could differentiate between populations with higher and lower 2‐year risk of severe hypoglycaemia among individuals at increased risk of …

Continue reading Development of a #hypoglycaemia risk score to identify high‐risk individuals with advanced type 2 diabetes in DEVOTE

Assessment of #dextrose 50 bolus versus dextrose 10 infusion in the management of #hyperkalemia in the ED

Hypoglycemia is a common adverse effect when intravenous (IV) insulin is administered for hyperkalemia. A prolonged infusion of dextrose 10% (D10) may mitigate hypoglycemia compared to dextrose 50% (D50) bolus. Our objective was to evaluate whether D10 infusion is a safe and effective alternative to D50 bolus for hypoglycemia prevention in hyperkalemic patients receiving IV …

Continue reading Assessment of #dextrose 50 bolus versus dextrose 10 infusion in the management of #hyperkalemia in the ED

Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study

STUDY OBJECTIVES:Intensive care unit (ICU) nurses commonly work multiple consecutive 12-hr shifts that leave little time for sleep between work shifts. Working multiple consecutive shifts could compromise vigilance and patient care, especially with respect to managing high risk medications such as insulin infusions.. We identified patients who had hypoglycemia (glucose <=3.5mmol/l, 63 mg/dl) between December …

Continue reading Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study