Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

To investigate if the combination of biologics with methotrexate (MTX) would have better performance than biological monotherapy in clinical efficiency and safety for the treatment of psoriasis and psoriatic arthritis (PsA). Methods. A systematic review of randomized controlled trials (RCTs) searched from the Pubmed, Cochrane Library, and Embase was conducted. Psoriasis Area and Severity Index (PASI) responses (including PASI50,75 and 90), and proportion of patients … Continue reading Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

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Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

..There was an increased risk of several cancers, including keratinocyte cancer (RR, 2.28; 95% CI, 1.73-3.01), lymphomas (RR, 1.56; 95% CI, 1.37-1.78), lung cancer (RR, 1.26; 95% CI, 1.13-1.40), and bladder cancer (RR, 1.12; 95% CI, 1.04-1.19). No increased risk of cancer for patients with psoriasis treated with biologic agents was found (RR, 0.97; 95% CI, 0.85-1.10). Psoriatic arthritis was not associated with increased risk … Continue reading Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

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