Association of Cardiac Biomarkers with Cardiovascular Outcomes in Patients with Psoriatic Arthritis and Psoriasis: A Longitudinal Cohort Study

In patients with psoriatic disease (PsD), we determined whether cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) were associated with carotid plaque burden and the development of cardiovascular (CV) events independent of the Framingham Risk Score (FRS). MethodsAmong 1,000 patients with PsD, carotid total plaque area (TPA) was measured in 358 participants at …

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Role of nutritional supplements in selected dermatological disorders: A review

While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper …

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Trial of Spesolimab for Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in the pathogenesis of this disorder. Spesolimab, a humanized anti–interleukin-36 receptor monoclonal antibody, is being studied for the treatment of GPP flares. In a phase 2 trial, we randomly assigned patients with a …

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Prevalence of Nonradiographic #Sacroiliitis in Patients With Psoriatic #Arthritis: A Real-life Observational Study

To establish the prevalence of nonradiographic sacroiliitis within a real-life sample of patients with psoriatic arthritis (PsA), using pelvic radiographs and magnetic resonance imaging (MRI) of sacroiliac joints (SIJs). Methods. This cross-sectional study included 107 consecutive adults with PsA (Classification Criteria for Psoriatic Arthritis criteria). Participants completed clinical and laboratory evaluation, pelvic radiographs scored for …

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Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

To investigate if the combination of biologics with methotrexate (MTX) would have better performance than biological monotherapy in clinical efficiency and safety for the treatment of psoriasis and psoriatic arthritis (PsA). Methods. A systematic review of randomized controlled trials (RCTs) searched from the Pubmed, Cochrane Library, and Embase was conducted. Psoriasis Area and Severity Index …

Continue reading Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials