The purpose of this study was to analyze the clinical characteristics of chronic hepatitis B (CHB) cured by antiviral therapy.. ..The combined treatment time for all participants was 124.7 ± 58.8 weeks, and the average Peg-IFN treatment time was 102.6 ± 56.1 weeks. At 24 weeks, Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg) had decreased… Continue reading Clinical characteristics of chronic hepatitis B cured by peginterferon in combination with nucleotide analogs
Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial
Saturated-fat intake and endotoxemia can impair cognition. However, their acute impact on cognitive performance is unknown.. In this double-blind, randomized crossover trial, 51 women (n = 32 breast cancer survivors, n = 19 noncancer controls; mean ± SD age: 53 ± 8 y) completed the Continuous Performance Test (CPT) and had their blood drawn to… Continue reading Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial
#Metformin users with diabetes and individuals without #diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort
Several studies have reported the preventive effect of metformin on cancer development. This study aimed to investigate the relationship between use of metformin and risk of cancer in Koreans.. ..A total of 323,430 subjects was enrolled (301,905 individuals without diabetes [No DM], 8,643 diabetic patients with metformin treatment [metformin users], and 12,882 diabetic patients without… Continue reading #Metformin users with diabetes and individuals without #diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort
Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care
Evaluate efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) with 1-day initiation during hospitalization for acute exacerbation of schizophrenia followed by transition to outpatient care.. The phase 3b double-blind Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness (ALPINE) study was conducted from November 2017 to March 2019. Adults with acute schizophrenia according to… Continue reading Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care
Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels
Iodine has been suggested to protect against breast cancer, but there are no epidemiological studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g. Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g.… Continue reading Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels
Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States
In analyses of the effectiveness of response measures to the outbreak of coronavirus disease 2019 (COVID-19), most studies have used the number of confirmed cases or deaths. However, case count is a conservative estimate of the actual number of infected individuals in the absence of community-wide serologic testing. Death count is a lagging metric and… Continue reading Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States
#Anaemia, iron status, and gender predict the outcome in patients with chronic heart #failure
Anaemia and iron deficiency (ID) are frequently found in patients with chronic heart failure (CHF) and associated with adverse outcome. However, it is unclear whether absolute [transferrin saturation (TSAT) <20%, ferritin <100 μg/L] or inflammation‐driven functional ID (TSAT <20%, ferritin >100 μg/L) with and without anaemia had similar or different consequences for such patients Within… Continue reading #Anaemia, iron status, and gender predict the outcome in patients with chronic heart #failure
Adverse effects of electronic #cigarettes on the disease-naive oral #microbiome
Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbial functional dynamics, we discovered pathogen overrepresentation, higher virulence signatures, and a… Continue reading Adverse effects of electronic #cigarettes on the disease-naive oral #microbiome
#Cognitive behavioral group therapy for panic disorder in a general clinical setting: a prospective cohort study with 12 to 31-years follow-up
The long-term prognosis after cognitive behavioral therapy (CBT) in outpatient groups for panic disorder and agoraphobia is not well known. The purpose of this study was to assess long-term outcomes in terms of psychological health, health-related quality of life (HRQoL), quality of life (QoL) and treatment satisfaction after CBT for panic disorder and agoraphobia ..The… Continue reading #Cognitive behavioral group therapy for panic disorder in a general clinical setting: a prospective cohort study with 12 to 31-years follow-up
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