VTE Prophylaxis in Critically Ill AdultsA Systematic Review and Network Meta-analysis

BackgroundCritically ill adults are at increased risk of VTE, including DVT, and pulmonary embolism. Various agents exist for venous thromboprophylaxis in this population. Research QuestionWhat is the comparative efficacy and safety of prophylaxis agents for prevention of VTE in critically ill adults?Study Design and MethodsSystematic review and network meta-analysis of randomized clinical trials (RCTs) evaluating …

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The Serum Citrulline and D-Lactate are Associated with #Gastrointestinal Dysfunction and Failure in Critically #Ill Patients

This study attempted to screen and combine effective biomarkers to analyse the association between these biomarkers and gastrointestinal failure (GIF) in critically ill patients.Methods: A total of 110 critically ill patients with acute gastrointestinal injury (AGI) admitted to ICU were enrolled. The AGI grade was determined by the AGI classification proposed by ESICM. There were …

Continue reading The Serum Citrulline and D-Lactate are Associated with #Gastrointestinal Dysfunction and Failure in Critically #Ill Patients

The Relationship Between Prognostic #Nutritional Index and All-Cause #Mortality in Critically Ill Patients: A Retrospective Study

The effectiveness and prognostic value of the prognostic nutritional index (PNI) in critically ill patients are unknown. Hence, this study aimed to analyze the relationship between the PNI and all-cause mortality in critically ill patients. Patients and Methods: Patient data were obtained from the Multiparameter Intelligent Monitoring in Intensive Care III database. The relationship between …

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Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults

Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. Research Question Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? Study Design and Methods This study evaluated long-term …

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Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials

Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients. Seventy-four trials enrolling 39 …

Continue reading Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials