Vitamin #D receptor is overexpressed in the duodenum of patients with #irritable bowel syndrome

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders and bile acids are thought to be associated with the pathogenesis of IBS. Bile acid receptors are expressed on intestinal epithelial cells. However, no study has assessed bile acid receptor proteins in IBS. Therefore, we examined the intestinal mucosal expression of bile acid receptors in patients with IBS.. Intestinal biopsies were performed … Continue reading Vitamin #D receptor is overexpressed in the duodenum of patients with #irritable bowel syndrome

Heat-inactivated #Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of #irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial

Bifidobacterium bifidum MIMBb75 is one of a few probiotic strains that have been shown to be effective in the treatment of irritable bowel syndrome (IBS) and its symptoms. Non-viable strains might have advantages over viable bacteria for product stability and standardisation, as well as for tolerability because safety concerns have been raised for specific patient groups who are susceptible to infection.. ..Patients were screened between … Continue reading Heat-inactivated #Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of #irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial

Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss

..Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or #irritable bowel syndrome. We investigated the effects of infection-induced inflammation on intrinsic EANs (iEANs) and the role of intestinal muscularis macrophages (MMs) in this context Using murine … Continue reading Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss