We assessed the impact of total and partial sleep loss on neural correlates of fear conditioning and extinction learning and recall in healthy young adults. Methods Participants (56.3% female, age 24.8±3.4) were randomized to a night of normal sleep (NS, n=48), sleep restriction (SR, n=53), or sleep deprivation (SD, n=53). All completed fear conditioning and… Continue reading Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory
Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis
Guidelines recommend targeting preventive interventions toward older adults whose life expectancy is greater than the intervention’s time to benefit (TTB). The TTB for statin therapy is unknown To conduct a survival meta-analysis of randomized clinical trials of statins to determine the TTB for prevention of a first major adverse cardiovascular event (MACE) in adults aged… Continue reading Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis
A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of #COPD: the RESCUE trial
Exacerbations of COPD are one of the commonest causes of admission and readmission to hospital. The role of digital interventions to support self-management in improving outcomes is uncertain. We conducted an open, randomised controlled trial of a digital health platform application (app) in 41 COPD patients recruited following hospital admission with an acute exacerbation. Subjects… Continue reading A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of #COPD: the RESCUE trial
Effect of #caloric restriction with or without physical #activity on body composition and epicardial #fat in type 2 diabetic patients: a pilot randomized controlled trial
There is debate over the independent and combined effects of caloric restriction (CR) and physical activity (PA) on reduction in fat mass and in epicardial fat thickness. We compared the impact of a similar energy deficit prescription by CR or by CR combined with PA on total fat mass, epicardial fat thickness, and cardiometabolic profile… Continue reading Effect of #caloric restriction with or without physical #activity on body composition and epicardial #fat in type 2 diabetic patients: a pilot randomized controlled trial
A Placebo-Controlled Trial of Subcutaneous #Semaglutide in Nonalcoholic #Steatohepatitis
Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited. The efficacy and safety of the glucagon-like peptide-1 receptor agonist semaglutide in patients with NASH is not known.. ..In total, 320 patients (of whom 230 had stage F2 or F3 fibrosis) were randomly assigned to… Continue reading A Placebo-Controlled Trial of Subcutaneous #Semaglutide in Nonalcoholic #Steatohepatitis
#Dementia and the risk of death in elderly patients with #COVID‐19 infection: Systematic review and meta‐analysis
The COVID‐19 infection represents a global public health emergency worldwide. Several risk factors have been associated with a poor prognosis among COVID‐19 patients. We aimed to perform a systemic review and meta‐analysis to evaluate the mortality risk in elderly patients with dementia and COVID‐19 infection.. ..A total of 233 articles were retrieved; 158 were excluded… Continue reading #Dementia and the risk of death in elderly patients with #COVID‐19 infection: Systematic review and meta‐analysis
Polypill with or without Aspirin in Persons without #Cardiovascular Disease
..Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily, aspirin (75 mg) or placebo daily, and vitamin D or placebo… Continue reading Polypill with or without Aspirin in Persons without #Cardiovascular Disease
Association of Baseline and Longitudinal Changes in Body Composition Measures With Risk of #Heart Failure and Myocardial #Infarction in Type 2 #Diabetes: Findings From the Look AHEAD Trial
Lower abdominal and pelvic radiation and #testicular germ cell tumor risk
Testicular germ cell tumor (TGCT) incidence has increased in recent decades along with the use and dose of diagnostic radiation. Here we examine the association between reported exposure to diagnostic radiation and TGCT risk.. ..There were 315 men with TGCT and 931 men without TGCT in our study. Compared to no exposures, risk of TGCT… Continue reading Lower abdominal and pelvic radiation and #testicular germ cell tumor risk
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