To assess the use of proton pump inhibitors (PPIs) to treat persistent throat symptoms.. ..Random blinded allocation (1:1) to either 30 mg lansoprazole twice daily or matched placebo twice daily for 16 weeks. Main outcome measures Primary outcome was symptomatic response at 16 weeks measured using the total reflux symptom index (RSI) score. Secondary outcomes… Continue reading Use of #proton pump inhibitors to treat persistent #throat symptoms: multicentre, double blind, randomised, placebo controlled trial
Racial Disparities in Epigenetic Aging of the Right vs Left #Colon
There are well-documented racial differences in age-of-onset and laterality of colorectal cancer. Epigenetic age acceleration is postulated to be an underlying factor. However, comparative studies of side-specific colonic tissue epigenetic aging are lacking. Here, we performed DNA methylation analysis of matched right and left biopsies of normal colon from 128 individuals. Among African Americans (n = 88),… Continue reading Racial Disparities in Epigenetic Aging of the Right vs Left #Colon
#Renal Failure is Associated With Increased Mortality and Hospital Utilization in Patients Admitted With Nonalcoholic #Steatohepatitis
We aimed to investigate the mortality and hospital utilization outcomes of hospitalized nonalcoholic steatohepatitis (NASH) patients with and without kidney failure in a nationwide cohort.. ..The overall sample included 7,135,090 patients. Among 6855 patients admitted for NASH, 598 or 8.7% had comorbid kidney failure. After multivariate regression analysis, NASH patients with renal failure had increased… Continue reading #Renal Failure is Associated With Increased Mortality and Hospital Utilization in Patients Admitted With Nonalcoholic #Steatohepatitis
#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer's Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males,… Continue reading #Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless… Continue reading Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways
Predicted #Heart Age Among #Cancer Survivors
What is already known about this topic? Cancer and cardiovascular disease (CVD) share long-term risk factors. Physician-patient communication using heart age has been effective in motivating patients to improve modifiable CVD risk factors. What is added by this report? The predicted heart age and excess heart age among cancer survivors were 57.2 and 8.5 years,… Continue reading Predicted #Heart Age Among #Cancer Survivors
Early High-Titer #Plasma Therapy to Prevent Severe #Covid-19 in Older Adults
Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness. We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome… Continue reading Early High-Titer #Plasma Therapy to Prevent Severe #Covid-19 in Older Adults
AGA Clinical Practice Update on Medical Management of Colonic #Diverticulitis: Expert Review
Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictably and can lead to chronic gastrointestinal symptoms. Gastroenterologists commonly care for patients with this disease. The purpose of this Clinical Practice Update is to provide practical and evidence-based advice for management of diverticulitis. We reviewed systematic reviews, meta-analyses, randomized controlled trials, and observational studies to… Continue reading AGA Clinical Practice Update on Medical Management of Colonic #Diverticulitis: Expert Review
Association of #Fluoroquinolone Use With Short-term Risk of Development of Aortic #Aneurysm
Although fluoroquinolones are commonly prescribed antibiotics in the US, recent international studies have shown an increased risk of aortic aneurysm and dissection after fluoroquinolone use, leading to US Food and Drug Administration warnings limiting use for high-risk patients. It is unclear whether these data are true for the US population and who is truly high… Continue reading Association of #Fluoroquinolone Use With Short-term Risk of Development of Aortic #Aneurysm
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