Olfactory dysfunction is associated with the transition from normal cognition to dementia in persons without type 2 diabetes. This study aimed to investigate whether olfactory dysfunction could be an early marker of future dementia in older patients with type 2 diabetes. Methods This exploratory study included 151 older Japanese outpatients with type 2 diabetes who… Continue reading #Olfactory dysfunction predicts the development of #dementia in older patients with type 2 #diabetes
Prevalence of Central Nervous System–Active Polypharmacy Among Older Adults With #Dementia in the US
Community-dwelling older adults with dementia have a high prevalence of psychotropic and opioid use. In these patients, central nervous system (CNS)–active polypharmacy may increase the risk for impaired cognition, fall-related injury, and death. Objective To determine the extent of CNS-active polypharmacy among community-dwelling older adults with dementia in the US. Design, Setting, and Participants Cross-sectional… Continue reading Prevalence of Central Nervous System–Active Polypharmacy Among Older Adults With #Dementia in the US
Major GI #bleeding in older persons using #aspirin: incidence and risk factors in the ASPREE randomised controlled trial
There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial. Design Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010–2017 (‘ASPirin in Reducing Events in the Elderly… Continue reading Major GI #bleeding in older persons using #aspirin: incidence and risk factors in the ASPREE randomised controlled trial
#Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Patients with type 2 diabetes (T2D) are at increased risk of both cardiovascular disease (CVD) and advanced liver fibrosis related to non-alcoholic fatty liver disease (NAFLD). Statin use is known to reduce the incidence of CVD while evidence on an effect on NAFLD severity is limited. Methods This is a cross-sectional study performed with data… Continue reading #Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI). Methods We compared the risk for recurrent CVD events among US adults with health insurance who… Continue reading Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea
Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some studies validate the health benefits of tea, few have investigated the molecular mechanisms of action. The KCNQ5 voltage-gated potassium channel contributes to vascular smooth muscle tone and neuronal M-current regulation. Methods: We applied electrophysiology, myography, mass spectrometry… Continue reading KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea
ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional… Continue reading ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
As an active interface between the host and their diet, the gut microbiota influences host metabolic adaptation; however, the contributions of fungi have been overlooked. Here, we investigate whether variations in gut mycobiome abundance and composition correlate with key features of host metabolism. We obtained animals from four commercial sources in parallel to test if… Continue reading The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used. METHODS We performed a pragmatic, randomized trial comparing one-step screening (i.e., a glucose-tolerance test in which… Continue reading A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
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