Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation observed in stress-related psychiatric disorders. In this study, we show that FK506-binding protein 51 (FKBP5) plays a critical role in fine-tuning MR:GR balance in the… Continue reading #Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
Category: Endocrinology
#Thyroid Hormone Therapy and Incident #Stroke
Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors. ObjectiveDetermine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke. DesignRetrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months.… Continue reading #Thyroid Hormone Therapy and Incident #Stroke
Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
We aimed to examine the number of teeth and masticatory function as oral health indices and clarify their roles in the pathogenesis of sarcopenia and diabetes mellitus in community-dwelling older adults. Subjects and methodsThis cross-sectional study was conducted with 635 older adults in Ohnan, Shimane Prefecture, in rural Japan. The number of teeth and masticatory… Continue reading Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study
Associations Between #Fruit Intake and Risk of #Diabetes in the AusDiab Cohort
Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection. ObjectiveThe aims of this work were to examine associations between intake of fruit types and 1) measures of glucose tolerance and insulin sensitivity and 2) diabetes at follow-up.… Continue reading Associations Between #Fruit Intake and Risk of #Diabetes in the AusDiab Cohort
#Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
Our aim was to evaluate the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabetes. MethodsPost hoc analysis of changes in BP, antihypertensive medication prescriptions and symptoms during the initial total diet replacement phase was performed in… Continue reading #Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
#Thyroid dysfunction and #breast cancer risk among women in the UK Biobank cohort
This study aimed to evaluate the association between thyroid dysfunction and breast cancer risk. We included 239,436 females of the UK Biobank cohort. Information on thyroid dysfunction, personal and family medical history, medications, reproductive factors, lifestyle, and socioeconomic characteristics was retrieved from baseline self-reported data and hospital inpatient databases. Breast cancer diagnoses were identified through… Continue reading #Thyroid dysfunction and #breast cancer risk among women in the UK Biobank cohort
Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
High milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence (LCT-13910 C > T, rs4988235) variant as an instrumental variable. MethodsWe tested the association of LCT genotype with milk consumption (for validation) and with… Continue reading Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
#Cognitive Behavioral Approach to Treat #Obesity: A Randomized Clinical Trial
Our aim was to analyze and compare the effects of three different long-term treatments on anthropometric profiles, eating behaviors, anxiety and depression levels, and quality of life of groups of adults with obesity. Methods: The 43 participants in the study were randomly assigned to one of three groups: the education and health group (EH, n… Continue reading #Cognitive Behavioral Approach to Treat #Obesity: A Randomized Clinical Trial
Association Between Mortality and Levels of Autonomous #Cortisol Secretion by Adrenal #Incidentalomas
Autonomous cortisol secretion in patients with adrenal incidentalomas is associated with increased mortality, but detailed information about the risk associated with specific levels of autonomous cortisol secretion is not available. Objective:To measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas. Design:Retrospective cohort study. (ClinicalTrials.gov: NCT03919734) Setting:Two hospitals in… Continue reading Association Between Mortality and Levels of Autonomous #Cortisol Secretion by Adrenal #Incidentalomas
