Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced… Continue reading Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Category: Endocrinology
#Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Calcium (Ca) is an essential nutrient that may play an important role in weight maintenance through its involvement in energy or lipid metabolism. However, little is known about the long-term associations of Ca intake with obesity risk. ObjectivesWe aimed to prospectively examine the association between cumulative Ca intake and the incidence of obesity among American… Continue reading #Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women
The objective of this study was to analyze changes in serum markers of bone turnover across multiple decades in osteoporotic women compared with nonosteoporotic controls, to determine their utility as potential predictors for osteoporosis. Early prediction of those at risk for osteoporosis can enable early intervention before the irreversible loss of critical bone mass. MethodsSerum… Continue reading Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women
Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. We aimed to examine this association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions. MethodsIn this prospective, community-based, cohort study, we used de-identified patient-level data from the QResearch database of general practices in England, UK. We… Continue reading Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
A Randomized, Open-Label Comparison of Once-Weekly #Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
Insulin icodec is a novel once-weekly basal insulin analog. This trial investigated the efficacy and safety of icodec using different once-weekly titration algorithms. RESEARCH DESIGN AND METHODS This was a phase 2, randomized, open-label, 16-week, treat-to-target study. Insulin-naïve adults (n = 205) with type 2 diabetes and HbA1c 7–10% while treated with oral glucose-lowering medications… Continue reading A Randomized, Open-Label Comparison of Once-Weekly #Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
VPS39-deficiency observed in type 2 #diabetes impairs #muscle stem cell differentiation via altered autophagy and epigenetics
Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast differentiation and muscle glucose uptake, and VPS39 is downregulated in myoblasts… Continue reading VPS39-deficiency observed in type 2 #diabetes impairs #muscle stem cell differentiation via altered autophagy and epigenetics
Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK
Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantified. MethodsThis population-based cohort study used routine UK primary care electronic health data linked to secondary care and… Continue reading Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK
Therapeutic Repurposing of #Biguanides in #Cancer
Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides.… Continue reading Therapeutic Repurposing of #Biguanides in #Cancer
#Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis
Gastric cancer (GC) is the fifth diagnosed cancer worldwide and the third leading cause of death for cancer. Recent reports suggest that metabolic syndrome (MetS) has a role in etiology, progression or prognosis on GC. The aim of this study is to systematically review the evidence on the association between MetS and GC risk and… Continue reading #Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis
