#Thyroid Hormone Therapy and Incident #Stroke

Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors. ObjectiveDetermine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke. DesignRetrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months. …

Continue reading #Thyroid Hormone Therapy and Incident #Stroke

#Levothyroxine dose and risk of atrial #fibrillation: A nested case-control study

Contemporary data on the effect of levothyroxine dose on the occurrence of atrial fibrillation (AF) are lacking, particularly in the older population. Our objective was to determine the effect of cumulative levothyroxine exposure on risk of AF and ischemic stroke in older adults We conducted a population-based observational study using health care databases from Ontario, …

Continue reading #Levothyroxine dose and risk of atrial #fibrillation: A nested case-control study

The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility

..Thyroid function and thyroid peroxidase antibody (TPOAb) data were available for 19213 and 19237 women, respectively. The prevalence of abnormal thyroid function was 4.8% (95% CI, 4.5-5.1); euthyroidism was defined as levels of thyroid-stimulating hormone (TSH) of 0.44 to 4.50 mIU/L and free thyroxine (fT4) of 10 to 21 pmol/L. Overt hypothyroidism (TSH > 4.50 …

Continue reading The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility

L-Thyroxine Therapy for Older Adults With Subclinical #Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial

..132 participants had Hypothyroid Symptoms scores greater than 30, and 133 had Tiredness scores greater than 40. Among the group with high symptom burden, the Hypothyroid Symptoms score improved similarly between those receiving L-thyroxine (mean within-group change, −12.3 [95% CI, −16.6 to −8.0]) and those receiving placebo (mean within-group change, −10.4 [CI, −15.3 to −5.4]) …

Continue reading L-Thyroxine Therapy for Older Adults With Subclinical #Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial

Association Between #Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical #Hypothyroidism

..The hypothyroid symptoms score decreased from 21.7 at baseline to 19.3 at 12 months in the levothyroxine group vs from 19.8 at baseline to 17.4 at 12 months in the placebo group (adjusted between-group difference, 1.3 [95% CI, −2.7 to 5.2]; P = .53). The tiredness score increased from 25.5 at baseline to 28.2 at 12 months …

Continue reading Association Between #Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical #Hypothyroidism