Highlights•Sex-specific model reveals mechanisms of sexual dimorphism in glucose production.•Female model shows higher gluconeogenesis from glycerol during fasting.•TG-FFA cycle facilitates liver fat removal in females through TG secretion. AbstractMen generally favor carbohydrate metabolism, while women lean towards lipid metabolism, resulting in significant sex-based differences in energy oxidation across various metabolic states such as fasting and… Continue reading Modeling sex-specific whole-body metabolic responses to #feeding and #fasting
Author: aledopress
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#Arm Position and Blood #Pressure ReadingsThe ARMS Crossover Randomized Clinical Trial
Key PointsQuestion What is the effect of commonly used arm positions on blood pressure (BP) measurements compared to the standard, recommended position?Findings This crossover randomized clinical trial of 133 adults showed that supporting the arm on the lap overestimated systolic BP by 3.9 mm Hg and diastolic BP by 4.0 mm Hg. An unsupported arm… Continue reading #Arm Position and Blood #Pressure ReadingsThe ARMS Crossover Randomized Clinical Trial
Effects of reducing #sedentary behaviour on back pain, paraspinal muscle insulin sensitivity and muscle fat fraction and their associations: a secondary analysis of a 6-month randomised controlled trial
Objectives Sedentary behaviour (SB) is a plausible intervention target for back pain mitigation. Therefore, this study aimed to investigate the effects of a 6-month SB reduction intervention on back pain and related disability outcomes, and paraspinal muscle (ie, erector spinae and transversospinales separately) insulin sensitivity (glucose uptake, GU) and muscle fat fraction (FF).Methods Sixty-four adults… Continue reading Effects of reducing #sedentary behaviour on back pain, paraspinal muscle insulin sensitivity and muscle fat fraction and their associations: a secondary analysis of a 6-month randomised controlled trial
OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Background Children and adolescents in England were offered BNT162b2 as part of the national COVID-19 vaccine roll out from September 2021. We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.Methods With the approval of NHS England, we conducted an observational study in the OpenSAFELY-TPP… Continue reading OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
High #sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of #preeclampsia following assisted reproduction treatment
ObjectiveTo study the association between sperm deoxyribonucleic acid fragmentation index (DFI) and the odds of preeclampsia and other adverse perinatal outcomes after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. DesignA prospective cohort study including infertile couples undergoing conventional IVF or ICSI treatment and their children. Data regarding preeclampsia and perinatal outcomes were… Continue reading High #sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of #preeclampsia following assisted reproduction treatment
#GLP-1 programs the neurovascular landscape
Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an environment of overnutrition. This transformative setting has led to persistent health issues, such as obesity and metabolic syndrome. The development of glucagon-like peptide-1 receptor (GLP-1R) agonists reveals our ability to pharmacologically manage weight and address metabolic conditions. Obesity is directly linked to chronic… Continue reading #GLP-1 programs the neurovascular landscape
Identification of distinct #stool metabolites in women with #endometriosis for non-invasive diagnosis and potential for microbiota-based therapies
Context and significanceClinical management of endometriosis, a gynecological disease that is a leading cause of infertility in women, remains a challenge with no known cure. Scientists from Baylor College of Medicine combined the gut metabolomic and microbiota signatures in the stool samples from women with endometriosis to identify a gut-bacteria-derived therapeutic intervention candidate, 4-hydroxyindole. They… Continue reading Identification of distinct #stool metabolites in women with #endometriosis for non-invasive diagnosis and potential for microbiota-based therapies
#Mindfulness Meditation vs #Escitalopram for Treatment of #Anxiety DisordersSecondary Analysis of a Randomized Clinical Trial
IntroductionMindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), have shown efficacy for anxiety disorders.1 We previously demonstrated that 8 weeks of MBSR was noninferior to escitalopram for treatment of anxiety disorders in a fully powered, multisite, noninferiority parallel-group randomized clinical trial with a predetermined margin.2 We present secondary outcomes of the trial, including patient-reported anxiety,… Continue reading #Mindfulness Meditation vs #Escitalopram for Treatment of #Anxiety DisordersSecondary Analysis of a Randomized Clinical Trial
#Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America
Summary of Top 10 Key Points1. Approximately 6.7 million Americans over 20 years of age have heart failure (HF), and the prevalence is expected to rise to 8.5 million Americans by 2030.2. The lifetime risk of HF has increased to 24%; approximately 1 in 4 persons will develop HF in their lifetime.3. Approximately 33% of… Continue reading #Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America
2 Medical News 