Caloric restriction extends healthy lifespan in multiple species1. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored2,3,4,5,6,7,8. Identifying the most efficacious forms of dietary restriction is key for developing interventions to improve human health and longevity9. Here we performed an extensive assessment of graded… Continue reading #Dietary restriction impacts health and #lifespan of genetically diverse mice
Author: aledopress
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#Running is acceptable and efficacious in adults with non-specific chronic low #back pain: the ASTEROID randomised controlled trial
AbstractObjectives Running is one of the most accessible forms of exercise, yet its suitability for adults with chronic low back pain (LBP) is unknown. This study assessed the efficacy and acceptability of running in adults with chronic LBP.Methods This two-arm parallel (1:1) individually randomised controlled trial allocated 40 participants (mean (SD) age: 33 (6) years,… Continue reading #Running is acceptable and efficacious in adults with non-specific chronic low #back pain: the ASTEROID randomised controlled trial
#Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated… Continue reading #Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
#CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
While earlier first-generation epigenetic aging clocks were trained to estimate chronological age as accurately as possible, more recent next-generation clocks incorporate DNA methylation information more pertinent to health, lifestyle, and/or outcomes. Recently, we produced a non-invasive next-generation epigenetic clock trained using Infinium MethylationEPIC data from more than 8,000 diverse adult buccal samples. While this clock… Continue reading #CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
#Ultra-processed foods and health: are we correctly interpreting the available evidence?
Several studies have linked adverse health effects to the consumption of ultra-processed foods (UPF) according to the NOVA classification. However, whether the consumption of UPF is the actual causal factor for such health outcomes is still unknown. Indeed, different groups of UPF examined in the same epidemiologic study often show markedly different associations with the… Continue reading #Ultra-processed foods and health: are we correctly interpreting the available evidence?
Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Brazil #Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and #Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study)
BackgroundObesity is associated with low-grade inflammation and increased intestinal permeability (IP). The Brazil nut (BN) (Bertholletia excelsa H.B.K.) appears to be a promising dietary intervention to control inflammation by enhancing antioxidant defenses.ObjectivesWe aimed to assess the effect of daily BN consumption on inflammatory biomarkers and IP in the context of an energy-restricted intervention. Furthermore, we… Continue reading Brazil #Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and #Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study)
Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers. We performed a meta-analysis of randomized controlled trials (RCTs) published until March 2024 that reported estimates for the effects of… Continue reading Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
Several previous cross‐sectional studies suggested that body roundness index (BRI) may be associated with cardiovascular disease (CVD). However, the association should be further validated. Our study aimed to assess the association of the BRI trajectories with CVD among middle‐aged and older Chinese people in a longitudinal cohort.Methods and ResultsA total of 9935 participants from the… Continue reading Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
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