Over the past decades, people who inject drugs (PWID) have been impacted by the development of combination antiretroviral therapy (cART) to combat HIV/AIDS, the prescription opioid crisis, and increased use of lethal synthetic opioids. We measured how these dynamics have impacted mortality among PWID in an urban U.S. city. DesignProspective cohort study using data from… Continue reading Mortality among persons who inject #drugs: A prospective cohort followed over three decades in Baltimore, Maryland, USA
Author: aledopress
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Covid-19: #Delta infections threaten herd immunity #vaccine strategy
Epidemiologists are adjusting their expectations for the future course of the pandemic after data from a recent outbreak in Massachusetts in the US suggest that while vaccination remains highly protective against the worst consequences of infection, it may not be sufficient on its own to stop the spread of the delta variant. Testing conducted among… Continue reading Covid-19: #Delta infections threaten herd immunity #vaccine strategy
The Serum Citrulline and D-Lactate are Associated with #Gastrointestinal Dysfunction and Failure in Critically #Ill Patients
This study attempted to screen and combine effective biomarkers to analyse the association between these biomarkers and gastrointestinal failure (GIF) in critically ill patients.Methods: A total of 110 critically ill patients with acute gastrointestinal injury (AGI) admitted to ICU were enrolled. The AGI grade was determined by the AGI classification proposed by ESICM. There were… Continue reading The Serum Citrulline and D-Lactate are Associated with #Gastrointestinal Dysfunction and Failure in Critically #Ill Patients
#Plant‐Centered Diet and Risk of Incident #Cardiovascular Disease During Young to Middle Adulthood
The association between diets that focus on plant foods and restrict animal products and cardiovascular disease (CVD) is inconclusive. We investigated whether cumulative intake of a plant‐centered diet and shifting toward such a diet are associated with incident CVD. Methods and ResultsParticipants were 4946 adults in the CARDIA (Coronary Artery Risk Development in Young Adults)… Continue reading #Plant‐Centered Diet and Risk of Incident #Cardiovascular Disease During Young to Middle Adulthood
#NONALCOHOLIC FATTY LIVER DISEASE-RELATED RISK OF #CARDIOVASCULAR DISEASE AND OTHER CARDIAC COMPLICATIONS
Nonalcoholic fatty liver disease (NAFLD) affects approximately ~25% of the global adult population. The aim of this narrative review is to describe the associations between NAFLD and cardiovascular disease (CVD), arrhythmias, cardiac conduction defects, myocardial remodelling and heart failure. We also discuss the potential mechanisms that mediate or attenuate the strength of these associations, and… Continue reading #NONALCOHOLIC FATTY LIVER DISEASE-RELATED RISK OF #CARDIOVASCULAR DISEASE AND OTHER CARDIAC COMPLICATIONS
‘Mathematically Impossible’ for #Vaccines to Eliminate #COVID
The latest data suggest the wave of COVID among unvaccinated has peaked and natural herd immunity has set in, while vaccinated individuals are actually becoming more prone to infection The Defender is experiencing censorship on many social channels. Be sure to stay in touch with the news that matters by subscribing to our top news… Continue reading ‘Mathematically Impossible’ for #Vaccines to Eliminate #COVID
Functional human #IgA targets a conserved site on #malaria sporozoites
A role for IgA in malariaImmunoglobulin (Ig)A is known to play a protective role against pathogens at mucosal surfaces. However, the protective effects of IgA in the serum are less well understood, particularly in the context of pathogens such as Plasmodium falciparum. To address this question, Tan et al. isolated and characterized serum IgA from… Continue reading Functional human #IgA targets a conserved site on #malaria sporozoites
The changing characteristics of patients infected with chronic hepatitis #C virus from 2014 to 2019: Real-world data from the German #Hepatitis C-Registry (DHC-R)
The number of patients diagnosed with hepatitis C virus (HCV) is markedly higher than the number initiating treatment indicating gaps in the care cascade, likely centered around reaching at-risk populations. Understanding changing characteristics of patients with HCV allows for targeted programs that increase linkage to care. We investigated changes in demographic and clinical characteristics of… Continue reading The changing characteristics of patients infected with chronic hepatitis #C virus from 2014 to 2019: Real-world data from the German #Hepatitis C-Registry (DHC-R)
Influence of #angiotensin converting enzyme inhibitors/angiotensin receptor blockers on the risk of all-cause mortality and other clinical outcomes in patients with confirmed #COVID-19: A systemic review and meta-analysis
Since the COVID-19 pandemic, physicians concerned about the potential adverse effects of angiotensin converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs). To explore the relationship between ACEIs/ARBs and the risk of mortality and other clinical outcomes in COVID-19 patients, the authors conducted a systemic review and meta-analysis. An electronic search was performed from inception to November… Continue reading Influence of #angiotensin converting enzyme inhibitors/angiotensin receptor blockers on the risk of all-cause mortality and other clinical outcomes in patients with confirmed #COVID-19: A systemic review and meta-analysis
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