A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to… Continue reading High- #fat diet–induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
Author: aledopress
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Early detection of #COVID-19 in the UK using self-reported #symptoms: a large-scale, prospective, epidemiological surveillance study
.. The early detection of COVID-19 is helpful for resource allocation during the pandemic. Here, we have proposed a Bayesian approach to identify individuals with probable COVID-19 on the basis of self-reported symptoms during 1, 2, and 3 days after symptom onset and demographic information. Using a unique, prospective dataset, we evaluated the proposed method… Continue reading Early detection of #COVID-19 in the UK using self-reported #symptoms: a large-scale, prospective, epidemiological surveillance study
Infection-enhancing anti-#SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and #Delta variants. A potential risk for mass vaccination ?
Infection-enhancing antibodies have been detected in symptomatic Covid-19•Antibody dependent enhancement (ADE) is a potential concern for vaccines•Enhancing antibodies recognize both the Wuhan strain and Delta variants•ADE of Delta variants is a potential risk for current vaccines•Vaccine formulations lacking ADE epitope are suggested AbstractAntibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies.… Continue reading Infection-enhancing anti-#SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and #Delta variants. A potential risk for mass vaccination ?
Long-term night #shift work is associated with the risk of atrial #fibrillation and #coronary heart disease
The aim of this study was to test whether current and past night shift work was associated with incident atrial fibrillation (AF) and whether this association was modified by genetic vulnerability. Its associations with coronary heart disease (CHD), stroke, and heart failure (HF) were measured as a secondary aim. Methods and resultsThis cohort study included… Continue reading Long-term night #shift work is associated with the risk of atrial #fibrillation and #coronary heart disease
Environmental #Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries
Exposures to environmental pollutants during windows of developmental vulnerability in early life can cause disease and death in infancy and childhood as well as chronic, non-communicable diseases that may manifest at any point across the life span. Patterns of pollution and pollution-related disease change as countries move through economic development. Environmental pollution is now recognized… Continue reading Environmental #Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries
#Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study
A new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowledge, has not previously been described in detail. We aimed to document the features of post-vaccination cerebral venous thrombosis with and without… Continue reading #Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study
Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
To examine whether glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) are preferentially initiated among patients with cardiovascular disease, heart failure (HF), or nephropathy, where these drug classes have established benefit, compared with dipeptidyl peptidase 4 inhibitors (DPP-4i), for which corresponding benefits have not been demonstrated. RESEARCH DESIGN AND METHODS We… Continue reading Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
Identification of #antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results
Some antibiotic pairs display a property known as collateral sensitivity in which the evolution of resistance to one antibiotic increases sensitivity to the other. Alternating between collaterally sensitive antibiotics has been proposed as a sustainable solution to the problem of antibiotic resistance. We aimed to identify antibiotic pairs that could be considered for treatment strategies… Continue reading Identification of #antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results
Secondary organic aerosols from anthropogenic volatile organic compounds contribute substantially to air #pollution mortality
Anthropogenic secondary organic aerosol (ASOA), formed from anthropogenic emissions of organic compounds, constitutes a substantial fraction of the mass of submicron aerosol in populated areas around the world and contributes to poor air quality and premature mortality. However, the precursor sources of ASOA are poorly understood, and there are large uncertainties in the health benefits… Continue reading Secondary organic aerosols from anthropogenic volatile organic compounds contribute substantially to air #pollution mortality
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