Determination of optimal treatment durations for common infectious diseases is an important strategy to preserve antibiotic effectiveness. Objective To determine whether 7 days of treatment is noninferior to 14 days when using ciprofloxacin or trimethoprim/sulfamethoxazole to treat urinary tract infection (UTI) in afebrile men. Design, Setting, and Participants Randomized, double-blind, placebo-controlled noninferiority trial of afebrile… Continue reading Effect of 7 vs 14 Days of #Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With #Urinary Tract InfectionA Randomized Clinical Trial
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Extrapolating Long-term Event-Free and Overall Survival With #Dapagliflozin in Patients With #Heart Failure and Reduced #Ejection Fraction
Sodium glucose cotransporter 2 inhibitors reduce morbidity and mortality in patients with heart failure and reduced ejection fraction (HFrEF). Clinicians may find estimates of the projected long-term benefits of sodium glucose cotransporter 2 inhibitors a helpful addition to clinical trial results when communicating the benefits of this class of drug to patients. Objective To estimate… Continue reading Extrapolating Long-term Event-Free and Overall Survival With #Dapagliflozin in Patients With #Heart Failure and Reduced #Ejection Fraction
Favorable outcome on viral load and culture viability using #Ivermectin in early treatment of non-hospitalized patients with mild #COVID-19 – A double-blind, randomized placebo-controlled trial
Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection. Methods The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3 days vs. placebo in non-hospitalized COVID-19 patients. RT-PCR from a nasopharyngeal swab was obtained at… Continue reading Favorable outcome on viral load and culture viability using #Ivermectin in early treatment of non-hospitalized patients with mild #COVID-19 – A double-blind, randomized placebo-controlled trial
Ultra-processed #foods consumption and #diet quality of European children, adolescents and adults: results from the I.Family study
Energy intake from Ultra Processed Foods (UPFs) represents almost half of the daily energy intake within our study population, and this trend decrease progressively with age with no differences by cultural and socio-economic status.•Considering the quintiles of the dietary share of UPFs, energy intake increases across the quintiles, and diet quality is significantly lower in… Continue reading Ultra-processed #foods consumption and #diet quality of European children, adolescents and adults: results from the I.Family study
Association of #alcohol consumption with morbidity and mortality in patients with #cardiovascular disease: original data and meta-analysis of 48,423 men and women
Light-to-moderate alcohol consumption has been reported to be cardio-protective among apparently healthy individuals; however, it is unclear whether this association is also present in those with disease. To examine the association between alcohol consumption and prognosis in individuals with pre-existing cardiovascular disease (CVD), we conducted a series of meta-analyses of new findings from three large-scale… Continue reading Association of #alcohol consumption with morbidity and mortality in patients with #cardiovascular disease: original data and meta-analysis of 48,423 men and women
Serum #albumin and risks of hospitalization and death: Findings from the #Atherosclerosis Risk in Communities study
To determine whether lower serum albumin in community-dwelling, older adults is associated with increased risk of hospitalization and death independent of pre-existing disease. DesignProspective cohort study of participants in the fifth visit of the Atherosclerosis Risk in Communities (ARIC) study. Baseline data were collected from 2011 to 2013. Follow-up was available to December 31, 2017.… Continue reading Serum #albumin and risks of hospitalization and death: Findings from the #Atherosclerosis Risk in Communities study
#Meal composition during an ad libitum buffet meal and longitudinal predictions of #weight and percent body fat change: The role of hyper-palatable, energy dense, and ultra-processed foods
Foods that increase obesity risk are ubiquitous in the US food environment. Such foods may be the target of hedonic eating, which may facilitate weight gain and lead to obesity. The study tested whether meal composition during an ad libitum buffet meal was associated with 1-year weight and percent body fat changes among healthy younger… Continue reading #Meal composition during an ad libitum buffet meal and longitudinal predictions of #weight and percent body fat change: The role of hyper-palatable, energy dense, and ultra-processed foods
Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
RBC long-chain omega-3 (n–3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction. ObjectivesThe objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD)… Continue reading Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
Vaccinated and unvaccinated individuals have similar viral #loads in communities with a high prevalence of the #SARS-CoV-2 delta variant
SARS-CoV-2 variant B.1.617.2 (delta) is associated with higher viral loads [1] and increased transmissibility relative to other variants, as well as partial escape from polyclonal and monoclonal antibodies [2]. The emergence of the delta variant has been associated with increasing case counts and test-positivity rates, indicative of rapid community spread. Since early July 2021, SARS-CoV-2… Continue reading Vaccinated and unvaccinated individuals have similar viral #loads in communities with a high prevalence of the #SARS-CoV-2 delta variant
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