BACKGROUNDBetween 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed in 2664 men. Of these men, 1643 were enrolled in a trial to evaluate the effectiveness of treatments, with 545 randomly assigned to receive active monitoring, 553… Continue reading Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
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Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Multiple lines of evidence support the value of moderate fever to host survival, but the mechanisms involved remain unclear. This is difficult to establish in warm-blooded animal models, given the strict programmes controlling core body temperature and the physiological stress that results from their disruption. Thus, we took advantage of a cold-blooded teleost fish that… Continue reading Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis
Background Dietary modification is a cornerstone of cardiovascular disease (CVD) prevention. A Mediterranean diet has been associated with a lower risk of CVD but no systematic reviews have evaluated this relationship specifically in women.Objective To determine the association between higher versus lower adherence to a Mediterranean diet and incident CVD and total mortality in women.Methods… Continue reading Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis
Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study
The complexity of sleep hinders the formulation of sleep guidelines. Recent studies suggest that different unhealthy sleep characteristics jointly increase the risks for cardiovascular disease (CVD). This study aimed to estimate the differences in CVD-free life expectancy between people with different sleep profiles.MethodsWe included 308,683 middle-aged adults from the UK Biobank among whom 140,181 had… Continue reading Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study
Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5
Biotherapies targeting IL-5 allow a tangible improvement of asthma. However, all patients do not respond the same way to these treatments. Even if high blood eosinophil counts seem to be associated with a reduction in exacerbations with treatment targeting IL-5, we lack biomarkers for the prediction of remission after these very expensive treatments.Research QuestionDoes the… Continue reading Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5
Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study
Depression has been reported to be a risk factor for acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke typeMethodsINTERSTROKE is an international case-control study of risk… Continue reading Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study
Are the different cut-off points for sitting time associated with excess weight in adults? A population based study in Latin America
Excess weight is increasing worldwide, and in Latin America more than half of the population is excess weight. One of the reasons for this increase has been excessive sitting time. Still, it remains to be seen whether there is an excessive amount of that time in Latin American adults. This study aimed to associate different… Continue reading Are the different cut-off points for sitting time associated with excess weight in adults? A population based study in Latin America
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of aging-associated neurological disorders. Experimental therapies aimed at boosting brain NAD+ levels normalize several neurodegenerative phenotypes in animal models, motivating their clinical translation. Dietary intake of NAD+ precursors, such as nicotinamide riboside… Continue reading Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Outsourcing health-care services to the private sector and treatable mortality rates in England, 2013–20: an observational study of NHS privatisation
BackgroundThe effects of outsourcing health services to for-profit providers are contested, with some arguing that introducing such providers will improve performance through additional competition while others worry that this will lead to cost cutting and poorer outcomes for patients. We aimed to examine this debate by empirically evaluating the impact of outsourced spending to private… Continue reading Outsourcing health-care services to the private sector and treatable mortality rates in England, 2013–20: an observational study of NHS privatisation
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