Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups

Bacteria play a suspected role in the development of several cancer types, and associations between the presence of particular bacteria and prostate cancer have been reported. ObjectiveTo provide improved characterisation of the prostate and urine microbiome and to investigate the prognostic potential of the bacteria present. Design, setting, and participantsMicrobiome profiles were interrogated in sample …

Continue reading Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups

Impact of #diverticular disease on #prostate cancer risk among #hypertensive men

Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa. MethodsHypertensive …

Continue reading Impact of #diverticular disease on #prostate cancer risk among #hypertensive men

The association between occupational #asbestos exposure with the risk of incidence and mortality from #prostate #cancer: a systematic review and meta-analysis

There is conflicting evidence on the association between asbestos exposure and prostate cancer (PCa). Two recent meta-analyses have claimed that exposure is associated with increased PCa incidence and mortality, but they suffer from some methodological flaws. Given the potential importance of this research question, we aimed to perform a methodologically sound systematic review and meta-analysis …

Continue reading The association between occupational #asbestos exposure with the risk of incidence and mortality from #prostate #cancer: a systematic review and meta-analysis

#Ejaculation Frequency and Risk of #Prostate Cancer: Updated Results with an Additional Decade of Follow-up

Evidence suggests that ejaculation frequency may be inversely related to the risk of prostate cancer (PCa), a disease for which few modifiable risk factors have been identified. ObjectiveTo incorporate an additional 10 yr of follow-up into an original analysis and to comprehensively evaluate the association between ejaculation frequency and PCa, accounting for screening, clinically relevant …

Continue reading #Ejaculation Frequency and Risk of #Prostate Cancer: Updated Results with an Additional Decade of Follow-up

Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing #Parkinson Disease

Parkinson disease (PD) is a common neurodegenerative disease. A treatment that prevents or delays development of PD is a critical unmet need. Terazosin and closely related drugs were recently discovered to enhance glycolysis and reduce PD progression in animal models and human clinical databases.. ..A cohort of 52 365 propensity score–matched pairs of terazosin/doxazosin/alfuzosin and tamsulosin …

Continue reading Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing #Parkinson Disease