BackgroundThe effects of outsourcing health services to for-profit providers are contested, with some arguing that introducing such providers will improve performance through additional competition while others worry that this will lead to cost cutting and poorer outcomes for patients. We aimed to examine this debate by empirically evaluating the impact of outsourced spending to private… Continue reading Outsourcing health-care services to the private sector and treatable mortality rates in England, 2013–20: an observational study of NHS privatisation
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Elevated Blood Pressure and Worsening Cardiac Damage During Adolescence
ObjectivesTo examine the longitudinal course for the development of elevated blood pressure (BP)/hypertension and cardiac damage in adolescents.Study designFrom the Avon Longitudinal Study of Parents and Children, UK birth cohort, 1856 (1011 females) 17-year-olds were followed-up for 7 years. BP and echocardiography were assessed at ages 17 and 24 years. Elevated/hypertensive BP was defined as… Continue reading Elevated Blood Pressure and Worsening Cardiac Damage During Adolescence
Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
IntroductionDespite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center.MethodsBaseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves… Continue reading Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
IntroductionWe investigated associations of obesity with the expression of Alzheimer's disease (AD)–related genes in a large community-based cohort.MethodsThe sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist-to-hip ratio (WHR). Gene expression was measured for a set of 74 AD-related genes, derived by integrating genome-wide association… Continue reading Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
The artificial sweetener erythritol and cardiovascular event risk
Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200), circulating levels of multiple polyol sweeteners, especially erythritol,… Continue reading The artificial sweetener erythritol and cardiovascular event risk
Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 DiabetesA Randomized Clinical Trial
Importance In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death. Calcium channel blockers reduce these effects and may be beneficial to beta cell preservation in type 1 diabetes.Objective To determine the effect of verapamil on pancreatic beta cell function in children and adolescents with newly… Continue reading Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 DiabetesA Randomized Clinical Trial
Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
BackgroundInsomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI.MethodsPubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among… Continue reading Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
The ideal exercise time of day (ETOD) remains elusive regarding simultaneous effects on health and performance outcomes, especially in women.Purpose: Given known sex differences in response to exercise training, this study quantified health and performance outcomes in separate cohorts of women and men adhering to different ETOD.Methods: Thirty exercise-trained women (BMI = 24 ± 3… Continue reading Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.MethodsParticipants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class… Continue reading Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
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