Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food staples, but its role in CVD is not well understood. In this study, untargeted metabolomics analysis of fasting plasma from stable cardiac patients in a prospective discovery cohort… Continue reading A terminal metabolite of niacin promotes vascular inflammation and contributes to #cardiovascular disease risk
Effects of #mouthwash on #periodontal pathogens and glycemic control in patients with type 2 #diabetes mellitus
Periodontitis is known to be associated with type 2 diabetes mellitus (T2DM), and gargling with mouthwash is known to reduce the incidence of periodontitis by inhibiting periodontal pathogens. However, the effects of mouthwash on oral and systemic conditions in patients with T2DM remain unknown. In this study, we investigated the effects of gargling with mouthwash… Continue reading Effects of #mouthwash on #periodontal pathogens and glycemic control in patients with type 2 #diabetes mellitus
#Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study… Continue reading #Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
Most #GLP-1 Medications Correlated with a Lower Likelihood of #Anxiety and #Depression Diagnoses
Key FindingsDiabetic patients prescribed tirzepatide, semaglutide, dulaglutide, and exenatide are less likely to be diagnosed with depression after starting the medication compared to those not on a glucagon-like peptide-1 receptor agonist (GLP-1) medication. The likelihood of anxiety in diabetic patients is lower for those on all five GLP-1 medications studied. Among non-diabetic patients, semaglutide is correlated with… Continue reading Most #GLP-1 Medications Correlated with a Lower Likelihood of #Anxiety and #Depression Diagnoses
Wet Skin and Lightning
Vitamin #D and Marine n-3 #Fatty Acids for #Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
ObjectiveIn the 5.3 year randomized, 2 x 2 factorial, double-blind, placebo-controlled VITamin D and OmegA-3 TriaL (VITAL), vitamin D supplementationreduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval 0.61-0.99). Omega-3(n-3) fatty acid supplementation showed a statistically non-significant reduction (HR 0.85, 0.67-1.08). We aimed to confirm further AD cases arising during and after randomization and… Continue reading Vitamin #D and Marine n-3 #Fatty Acids for #Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
AbstractBackgroundUse of multivitamin supplements has been associated with lower incidence of colorectal cancer (CRC). However, its influence on CRC survival remains unknown.MethodsAmong 2424 patients with stage I–III CRC who provided detailed information about multivitamin supplements in the Nurses’ Health Study and Health Professionals Follow-up Study, the authors calculated multivariable hazard ratios (HRs) of multivitamin supplements… Continue reading Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
Effect of #Tai Chi vs Aerobic #Exercise on Blood #Pressure in Patients With PrehypertensionA Randomized Clinical Trial
Importance Prehypertension increases the risk of developing hypertension and other cardiovascular diseases. Early and effective intervention for patients with prehypertension is highly important.Objective To assess the efficacy of Tai Chi vs aerobic exercise in patients with prehypertension.Design, Setting, and Participants This prospective, single-blinded randomized clinical trial was conducted between July 25, 2019, and January 24, 2022, at 2… Continue reading Effect of #Tai Chi vs Aerobic #Exercise on Blood #Pressure in Patients With PrehypertensionA Randomized Clinical Trial
Elevated body #temperature is associated with #depressive symptoms: results from the TemPredict Study
Correlations between altered body temperature and depression have been reported in small samples; greater confidence in these associations would provide a rationale for further examining potential mechanisms of depression related to body temperature regulation. We sought to test the hypotheses that greater depression symptom severity is associated with (1) higher body temperature, (2) smaller differences… Continue reading Elevated body #temperature is associated with #depressive symptoms: results from the TemPredict Study
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