#Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients

Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of similar severity are lacking. Methods 22 COVID-19+ and 20 COVID-19– patients with respiratory failure admitted to intensive care were studied longitudinally. Demographic and clinical data were obtained from the day of admission. APLA testing included anticardiolipin (aCL), anti-β2glycoprotien … Continue reading #Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients

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Association of Maternal #Autoimmune Disease With #Attention-Deficit/Hyperactivity Disorder in Children

Maternal autoimmune disease has been associated with increased risk of neurodevelopmental disorders in offspring, but few studies have assessed the association with attention-deficit/hyperactivity disorder (ADHD).. ..In the population-based cohort analysis, 831 718 singleton, term infants born to 831 718 mothers (mean [SD] age, 29.8 [5.6] years) were assessed. Of 12 767 infants (1.5%) who were linked to a maternal autoimmune diagnosis, 12 610 were propensity score matched to 50 440 … Continue reading Association of Maternal #Autoimmune Disease With #Attention-Deficit/Hyperactivity Disorder in Children

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Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus

The existence of a diabetic cardiomyopathy has been postulated to explain the increased risk of heart failure (HF) in patients with diabetes mellitus; however, whether mechanisms specific to type 1 diabetes mellitus (T1DM) affect the myocardium is unclear. We have recently shown that poor glycemic control in patients with T1DM followed in the DCCT (Diabetes Control and Complications Trial), but not in patients with type … Continue reading Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus

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