..Considering the anti‐inflammatory and antibacterial effect of atorvastatin, the present study aimed at adding this agent to a four‐drug regimen in order to eradicate H. pylori. In the current study, 110 patients in the control group received a 14‐day regimen of amoxicillin, clarithromycin, bismuth, and esomeprazole, and 110 patients in the intervention group received 40… Continue reading Atorvastatin in combination with conventional antimicrobial treatment of #Helicobacter pylori eradication: A randomized controlled clinical trial
Effect of hormone replacement therapy on #atherogenic lipid profile in postmenopausal women
..Recent studies suggest that hormone replacement therapy (#HRT) is cardioprotective when initiated early after menopause, but the mechanisms involved are still unclear. One-hundred and forty postmenopausal women <70 years were included in EVTET and randomized either to active treatment (one tablet of 2 mg estradiol and 1 mg norethisterone acetate daily) (n = 71) or placebo (n = 69). Our study show… Continue reading Effect of hormone replacement therapy on #atherogenic lipid profile in postmenopausal women
A Screening Algorithm for Obstructive Sleep #Apnea in #Pregnancy
Obstructive sleep apnea (#OSA) is common in pregnancy and associated with maternal and fetal complications. Early detection of OSA may have important implications for maternal-fetal well-being. A screening tool combining several methods of assessment may better predict OSA among pregnant women compared with tools that rely solely on self-reported information.. Participants’ mean age was 27.4 ± 7.0… Continue reading A Screening Algorithm for Obstructive Sleep #Apnea in #Pregnancy
The bright side of dark: Exploring the positive effect of #narcissism on perceived stress through mental toughness
Previous research reported that Subclinical Narcissism (SN) may increase Mental #Toughness (MT) resulting in positive outcomes such as lower psychopathy, higher school grades and lower symptoms of depression. We conducted three studies (N = 364, 240 and 144 for studies 1, 2 and 3, respectively) to test a mediation model, which suggests that SN may increase MT… Continue reading The bright side of dark: Exploring the positive effect of #narcissism on perceived stress through mental toughness
Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor… Continue reading Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Smaller right dorsolateral prefrontal cortex (DLPFC; i.e., middle and superior frontal gyri) and insula GMVs were associated with increased alcohol use across samples. Family-based and prospective longitudinal data suggest these associations are genetically-conferred and that DLPFC GMV prospectively predicts future use and initiation. Genomic risk for alcohol use was enriched in gene-sets preferentially expressed in… Continue reading Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Comparing the burdens of opportunistic #infections among patients with systemic #rheumatic diseases: a nationally representative cohort study
The IR of opportunistic infections was highest for PM/DM cases (61.3/1000 person-years, 95% confidence interval [CI] 56.6–66.2), followed by SLE cases (43.1/1000 person-years, 95% CI 41.7–44.5), SSc cases (31.6/1000 person-years, 95% CI 28.3–35.1), RA cases (25.0/1000 person-years, 95% CI 24.4–25.7), and pSS cases (24.1/1000 person-years, 95% CI 23.1–25.2). Multivariable Cox analysis revealed that, relative to… Continue reading Comparing the burdens of opportunistic #infections among patients with systemic #rheumatic diseases: a nationally representative cohort study
Efficacy and safety of #anti-inflammatory agents for the treatment of major #depressive disorder: a systematic review and meta-analysis of randomised controlled trials
..Four studies explored the antidepressant effects of NSAIDs in addition to traditional antidepressants. In all four studies, celecoxib was added at the same dose (400 mg/day). Traditional antidepressants used were sertraline, fluoxetine and reboxetine. We combined these studies for a subgroup meta-analysis, finding that antidepressants combined with celecoxib were better than antidepressants alone, leading to a… Continue reading Efficacy and safety of #anti-inflammatory agents for the treatment of major #depressive disorder: a systematic review and meta-analysis of randomised controlled trials
Serum elaidic acid concentration and risk of #dementia. The Hisayama study
The associations between #trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for… Continue reading Serum elaidic acid concentration and risk of #dementia. The Hisayama study
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