Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. We aimed to study the incidence of hepatocellular carcinoma (HCC) and cirrhotic complications in psychiatric patients.. ..We included 105,763 psychiatric patients without prior liver-related events in the final… Continue reading High incidence of #hepatocellular carcinoma and #cirrhotic complications in patients with psychiatric illness: a territory-wide cohort study
Mathematical Modeling of Interaction between Innate and Adaptive #Immune Responses in #COVID‐19 and Implications for Viral Pathogenesis
We have applied mathematical modeling to investigate the infections of the ongoing COVID‐19 pandemic caused by SARS‐CoV‐2 virus. We first validated our model using the well‐studied influenza viruses and then compared the pathogenesis processes between the two viruses. The interaction between host innate and adaptive immune responses was found to be a potential cause for… Continue reading Mathematical Modeling of Interaction between Innate and Adaptive #Immune Responses in #COVID‐19 and Implications for Viral Pathogenesis
Inflammatory modulation of #fluoxetine use in patients with #depression: A systematic review and meta-analysis
There is growing evidence that there is a relationship between major depressive disorder (MDD), also simply known as “depression”, and inflammatory processes. Selective serotonin inhibitors, such as fluoxetine, are used as a first-line treatment for depression, and it is hypothesized that its use can reduce levels of proinflammatory cytokines. The aim of this systematic review… Continue reading Inflammatory modulation of #fluoxetine use in patients with #depression: A systematic review and meta-analysis
Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks
The emergence of a pandemic affecting the respiratory system can result in a significant demand for face masks. This includes the use of cloth masks by large sections of the public, as can be seen during the current global spread of COVID-19. However, there is limited knowledge available on the performance of various commonly available… Continue reading Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks
Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies
..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis… Continue reading Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies
Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4
Background Alcoholic liver disease (ALD) is a public health concern that is the cause of half of all cirrhosis‐related deaths. Early detection of fibrosis, ideally in the pre‐cirrhotic stage, is a key strategy for improving ALD outcomes and for preventing progression to cirrhosis. Previous studies identified the blood‐borne marker human microfibrillar‐associated protein 4 (MFAP4) as… Continue reading Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4
Dietary Patterns Are Associated with Likelihood of Hepatic #Steatosis among US Adults
Non‐alcoholic fatty liver disease (NAFLD) is a rapidly growing public health problem. In this study, we explored the association between dietary patterns (DPs) and fatty liver and liver function tests.. ..Of the 20643 eligible participants, 45.7% had prevalent fatty liver. Three DPs collectively explained 50.8% of variance in dietary nutrients consumption. The first DP was… Continue reading Dietary Patterns Are Associated with Likelihood of Hepatic #Steatosis among US Adults
Sputum #microbiome profiles identify severe #asthma phenotypes of relative stability at 12-18 months
..Data were available for 100 severe asthma subjects (median age: 55 yrs, 42% males). Two microbiome-driven clusters were identified, characterized by differences in asthma onset, smoking status, residential locations, percentage of blood and/or sputum neutrophils and macrophages, lung spirometry, and concurrent asthma medications (all p-values <.05). Cluster 2 patients displayed a commensal-deficient bacterial profile which… Continue reading Sputum #microbiome profiles identify severe #asthma phenotypes of relative stability at 12-18 months
Use of sodium-glucose co-transporter 2 inhibitors and risk of serious #renal events: Scandinavian cohort study
..Cohort of 29 887 new users of SGLT2 inhibitors (follow-up time: dapagliflozin 66.1%; empagliflozin 32.6%; canagliflozin 1.3%) and 29 887 new users of an active comparator, dipeptidyl peptidase-4 inhibitors, matched 1:1 on the basis of a propensity score with 57 variables. Mean follow-up time was 1.7 (SD 1.0) years. ..The mean age of the study population was… Continue reading Use of sodium-glucose co-transporter 2 inhibitors and risk of serious #renal events: Scandinavian cohort study
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