..Twenty-four women (5%) and 75 men (15%) were diagnosed with coronary artery disease by invasive coronary angiography or CT angiography during regular care follow-up. Elastic net regression was performed to assess which chest pain characteristics and risk factors were of diagnostic value. The overall model selected age, provocation by temperature or stress, relief at rest… Continue reading #Coronary artery disease prediction in women and men using chest pain characteristics and risk factors: an observational study in outpatient clinics
Emotional #Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway
..SIGNIFICANCE STATEMENT Astrocytes play important roles in synaptic transmission by extending fine processes around synapses. In this study, we showed that a single exposure to an acute stress triggered a retraction of lateral/fine processes in mouse cerebellar astrocytes. These astrocytes express GluA1, a glutamate receptor subunit known to lengthen astrocyte processes. We showed that astrocytic… Continue reading Emotional #Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway
#Mood Homeostasis, Low Mood, and History of #Depression in 2 Large Population Samples
..To assess whether mood homeostasis (ie, the stabilization of one’s mood by engaging in mood-modifying activities) is a possible new therapeutic target by testing the hypothesis that people with low (vs high) mean mood and people with (vs without) a history of depression have impaired mood homeostasis.. ..A total of 28 212 participants from the 58sec… Continue reading #Mood Homeostasis, Low Mood, and History of #Depression in 2 Large Population Samples
Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.
During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The… Continue reading Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.
Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation
Circadian (daily) regulation of metabolic pathways implies that food may be metabolized differentially over the daily cycle. To test that hypothesis, we monitored the metabolism of older subjects in a whole-room respiratory chamber over two separate 56-h sessions in a random crossover design. In one session, one of the 3 daily meals was presented as… Continue reading Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation
MEANINGFUL CHANGE IN SIX-MINUTE #WALK IN PEOPLE WITH PERIPHERAL #ARTERY DISEASE
Six-minute walk is a common outcome in clinical trials of people with lower extremity peripheral artery disease (PAD). However, meaningful change in six-minute walk distance is not well defined in people with PAD.. ..777 participants with PAD (mean age: 71.2 years (standard deviation (SD)=8.8) mean baseline six-minute walk: 350.1 meters (SD=118.1) completed 5,439 questions about… Continue reading MEANINGFUL CHANGE IN SIX-MINUTE #WALK IN PEOPLE WITH PERIPHERAL #ARTERY DISEASE
Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2
The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.. ..Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini‐Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone… Continue reading Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2
A 2-year Double-Blind RCT Follow-up Study with Fermented #Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered #Neurodegenerative Disease-Risk Factors
In recent years a number of studies have reported the significant relationship between metabolic syndrome and neurodegenerative disease. There is accumulating evidence that the interplay of combined genetic and environmental risk factors (from diet to life style to pollutants) to intrinsic age-related oxi-inflammatory changes may be advocated for to explain the pandemic of neurodegenerative diseases.… Continue reading A 2-year Double-Blind RCT Follow-up Study with Fermented #Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered #Neurodegenerative Disease-Risk Factors
#COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?
Since the declaration of COVID-19 pandemic infection by the World Health Organization, many governmental restrictions have been differently applied in the involved countries in order to contain the spread of the infection; Italy applied severe restrictive, public measures actually confining the entire population to an almost complete lockdown for several weeks; the restrictive quarantine can… Continue reading #COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?
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