..This study addresses two major challenges facing the treatment of stroke in the era of reperfusion therapy: hemorrhagic transformation and the disconnect between successful revascularization and functional outcomes. We studied how complement-dependent neuroinflammation drives the pathophysiology behind these challenges using a translationally relevant strategy. Complement inhibition was achieved using B4Crry, an injury site-targeted inhibitor of… Continue reading Complement-Dependent Synaptic Uptake and Cognitive Decline after #Stroke and Reperfusion Therapy
Associations of iron markers with type 2 #diabetes mellitus and metabolic syndrome: Results from the prospective SHIP study
To assess the role of serum ferritin and transferrin with prevalent and incident type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) and whether these associations are independent of inflammatory markers and hepatic enzymes.. Serum ferritin concentrations were associated with a higher prevalence of T2DM (total population OR: 1.16 [95% CI: 1.07, 1.26]; men OR:… Continue reading Associations of iron markers with type 2 #diabetes mellitus and metabolic syndrome: Results from the prospective SHIP study
p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators
High rates of glycolysis in cancer cells are a well-established characteristic of many human tumors, providing rapidly proliferating cancer cells with metabolites that can be used as precursors for anabolic pathways. Maintenance of high glycolytic rates depends on the lactate dehydrogenase–catalyzed regeneration of NAD+ from GAPDH-generated NADH because an increased NADH:NAD+ ratio inhibits GAPDH. Here,… Continue reading p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
coronavirus 2 (SARS-CoV-2) infection can spread rapidly within skilled nursing facilities. After identification of a case of Covid-19 in a skilled nursing facility, we assessed transmission and evaluated the adequacy of symptom-based screening to identify infections in residents.. ..Twenty-three days after the first positive test result in a resident at this skilled nursing facility, 57… Continue reading Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
Clinical characteristics of chronic hepatitis B cured by peginterferon in combination with nucleotide analogs
The purpose of this study was to analyze the clinical characteristics of chronic hepatitis B (CHB) cured by antiviral therapy.. ..The combined treatment time for all participants was 124.7 ± 58.8 weeks, and the average Peg-IFN treatment time was 102.6 ± 56.1 weeks. At 24 weeks, Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg) had decreased… Continue reading Clinical characteristics of chronic hepatitis B cured by peginterferon in combination with nucleotide analogs
Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial
Saturated-fat intake and endotoxemia can impair cognition. However, their acute impact on cognitive performance is unknown.. In this double-blind, randomized crossover trial, 51 women (n = 32 breast cancer survivors, n = 19 noncancer controls; mean ± SD age: 53 ± 8 y) completed the Continuous Performance Test (CPT) and had their blood drawn to… Continue reading Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial
#Metformin users with diabetes and individuals without #diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort
Several studies have reported the preventive effect of metformin on cancer development. This study aimed to investigate the relationship between use of metformin and risk of cancer in Koreans.. ..A total of 323,430 subjects was enrolled (301,905 individuals without diabetes [No DM], 8,643 diabetic patients with metformin treatment [metformin users], and 12,882 diabetic patients without… Continue reading #Metformin users with diabetes and individuals without #diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort
Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care
Evaluate efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) with 1-day initiation during hospitalization for acute exacerbation of schizophrenia followed by transition to outpatient care.. The phase 3b double-blind Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness (ALPINE) study was conducted from November 2017 to March 2019. Adults with acute schizophrenia according to… Continue reading Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care
Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels
Iodine has been suggested to protect against breast cancer, but there are no epidemiological studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g. Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g.… Continue reading Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels
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