Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality

Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 mmHg. However, all-cause mortality by attained BP in routine care in frail adults aged above 75 is unclear.. ..Risks of cardiovascular outcomes increased with SBPs >150 mmHg. Associations with mortality varied between non-frail <85 and … Continue reading Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality

Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in … Continue reading Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

Effects of total #sleep deprivation on procedural placekeeping: More than just lapses of attention

Total sleep deprivation (TSD) impairs attention as well as higher-order cognitive processes. Because attention is a core component of many tasks, it may fully mediate the effect of sleep deprivation on higher-order processes… A large sample of participants (N = 138 contributing data) performed the Psychomotor Vigilance Task and UNRAVEL under rested or sleep-deprived conditions. TSD impaired placekeeping generally and memory maintenance processes specifically, above … Continue reading Effects of total #sleep deprivation on procedural placekeeping: More than just lapses of attention