Background: Because many cases of coronavirus disease 2019 (COVID-19) are asymptomatic, generalizable data on the true number of persons infected are lacking. Mortality rates therefore are calculated from confirmed cases, which overestimates the infection fatality ratio (IFR). To calculate a true IFR, population prevalence data are needed from large geographic areas where reliable death data also exist. Most previous IFR estimates came from non-U.S. populations, … Continue reading Infection Fatality Ratios for #COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study
Hospitalized acutely ill medical patients are at risk for fatal and major thromboembolic events. Whether use of extended-duration primary thromboprophylaxis can prevent such events is unknown.. ..Medically ill patients with a baseline creatinine clearance ≥50 ml/min were randomized in a double-blind fashion to rivaroxaban 10 mg or placebo daily at hospital discharge for 45 days. Exploratory efficacy analyses were performed with the intent-to-treat population including … Continue reading Post-Discharge Prophylaxis With #Rivaroxaban Reduces Fatal and Major #Thromboembolic Events in Medically Ill Patients
..Recommendation: The WPSI recommends screening for anxiety in women and adolescent girls aged 13 years or older who are not currently diagnosed with anxiety disorders, including pregnant and postpartum women. Optimal screening intervals are unknown, and clinical judgment should be used to determine frequency. When screening suggests the presence of anxiety, further evaluation is necessary to establish the diagnosis and determine appropriate treatment and follow-up. … Continue reading Screening for Anxiety in Adolescent and Adult Women: A Recommendation From the Women’s Preventive Services Initiative
Since the declaration of COVID-19 pandemic infection by the World Health Organization, many governmental restrictions have been differently applied in the involved countries in order to contain the spread of the infection; Italy applied severe restrictive, public measures actually confining the entire population to an almost complete lockdown for several weeks; the restrictive quarantine can be considered controversial when excessively prolonged over time, due to … Continue reading #COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?
Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 mmHg. However, all-cause mortality by attained BP in routine care in frail adults aged above 75 is unclear.. ..Risks of cardiovascular outcomes increased with SBPs >150 mmHg. Associations with mortality varied between non-frail <85 and … Continue reading Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality
There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in … Continue reading Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Total sleep deprivation (TSD) impairs attention as well as higher-order cognitive processes. Because attention is a core component of many tasks, it may fully mediate the effect of sleep deprivation on higher-order processes… A large sample of participants (N = 138 contributing data) performed the Psychomotor Vigilance Task and UNRAVEL under rested or sleep-deprived conditions. TSD impaired placekeeping generally and memory maintenance processes specifically, above … Continue reading Effects of total #sleep deprivation on procedural placekeeping: More than just lapses of attention