Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of similar severity are lacking. Methods 22 COVID-19+ and 20 COVID-19– patients with respiratory failure admitted to intensive care were studied longitudinally. Demographic and clinical data were obtained from… Continue reading #Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients
Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. We aimed to examine this association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions. MethodsIn this prospective, community-based, cohort study, we used de-identified patient-level data from the QResearch database of general practices in England, UK. We… Continue reading Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis
The effects of pharmacological blood pressure lowering at normal or high-normal blood pressure ranges in people with or without pre-existing cardiovascular disease remains uncertain. We analysed individual participant data from randomised trials to investigate the effects of blood pressure lowering treatment on the risk of major cardiovascular events by baseline levels of systolic blood pressure.… Continue reading Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis
Automated quantitative thin slice volumetric low dose #CT analysis predicts disease severity in #COVID-19 patients
This study aimed to identify predictive (bio-)markers for COVID-19 severity derived from automated quantitative thin slice low dose volumetric CT analysis, clinical chemistry and lung function testing. MethodsSeventy-four COVID-19 patients admitted between March 16th and June 3rd 2020 to the Asklepios Lung Clinic Munich-Gauting, Germany, were included in the study. Patients were categorized in a… Continue reading Automated quantitative thin slice volumetric low dose #CT analysis predicts disease severity in #COVID-19 patients
Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis
To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. Design Systematic review and individual patient data meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Ovid Medline, Ovid Embase, EBSCO CINAHL Plus, and Web… Continue reading Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis
Effectiveness of #polymyxin B-immobilized hemoperfusion against #sepsis and septic #shock: A systematic review and meta-analysis
PurposeTo evaluate the efficacy and safety of Polymyxin B-immobilized hemoperfusion (PMX-HP) against sepsis or septic shock. MethodsWe searched databases (PubMed, EMBASE and Cochrane Library) to identify eligible randomized controlled trials (RCTs). The primary outcomes we included in this review were mortality at the longest follow-up available and serious adverse events associated with treatments. We used… Continue reading Effectiveness of #polymyxin B-immobilized hemoperfusion against #sepsis and septic #shock: A systematic review and meta-analysis
Early-life #environmental exposure determinants of child #behavior in Europe: A longitudinal, population-based study
BackgroundEnvironmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad spectrum of pre- and postnatal environmental exposures on child behavior. Methods and findingsWe used data from the HELIX (Human Early Life Exposome) project, which was… Continue reading Early-life #environmental exposure determinants of child #behavior in Europe: A longitudinal, population-based study
Effectiveness and Harms of High-Flow Nasal #Oxygen for Acute #Respiratory Failure: An Evidence Report for a Clinical Guideline From the American College of Physicians
Use of high-flow nasal oxygen (HFNO) for treatment of adults with acute respiratory failure (ARF) has increased. Purpose:To assess HFNO versus noninvasive ventilation (NIV) or conventional oxygen therapy (COT) for ARF in hospitalized adults. Data Sources:English-language searches of MEDLINE, Embase, CINAHL, and Cochrane Library from January 2000 to July 2020; systematic review reference lists. Study… Continue reading Effectiveness and Harms of High-Flow Nasal #Oxygen for Acute #Respiratory Failure: An Evidence Report for a Clinical Guideline From the American College of Physicians
A Randomized, Open-Label Comparison of Once-Weekly #Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
Insulin icodec is a novel once-weekly basal insulin analog. This trial investigated the efficacy and safety of icodec using different once-weekly titration algorithms. RESEARCH DESIGN AND METHODS This was a phase 2, randomized, open-label, 16-week, treat-to-target study. Insulin-naïve adults (n = 205) with type 2 diabetes and HbA1c 7–10% while treated with oral glucose-lowering medications… Continue reading A Randomized, Open-Label Comparison of Once-Weekly #Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
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