In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was observed. These improvements were so momentous that she was discharged from the hospice to a long-term care home. Based on this case, we conducted a… Continue reading Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs
The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. MethodsSera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative… Continue reading Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs
Western-style #diet impedes colonization and clearance of #Citrobacter rodentium
Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune system readiness, and thus host defense against pathogenic bacteria. Here we examined the impact of WSD on infection and colitis in response to… Continue reading Western-style #diet impedes colonization and clearance of #Citrobacter rodentium
MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies
The risk of being exposed to Covid-19 indoors can be as great at 60 feet as it is at 6 feet in a room where the air is mixed.Existing safety guidelines have omitted too many factors to accurately quantify the risk of airborne transmission, such as time, mask use and ventilation rates.Bazant and Bush question… Continue reading MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies
#Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort
Cognitive leisure activity, such as reading, playing mahjong or cards and computer use, is common among older adults in China. Previous studies suggest a negative correlation between cognitive leisure activity and cognitive impairment. However, the relationship between cognitive leisure activity and all-cause mortality has rarely been reported. ObjectivesThis study aims to explore the relationships between… Continue reading #Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort
Trends in Patient Characteristics and #COVID-19 In-Hospital #Mortality in the United States During the COVID-19 Pandemic
In-hospital mortality rates from COVID-19 are high but appear to be decreasing for selected locations in the United States. It is not known whether this is because of changes in the characteristics of patients being admitted. Objective To describe changing in-hospital mortality rates over time after accounting for individual patient characteristics. Design, Setting, and Participants… Continue reading Trends in Patient Characteristics and #COVID-19 In-Hospital #Mortality in the United States During the COVID-19 Pandemic
Systems level profiling of #chemotherapy-induced stress resolution in #cancer cells reveals druggable trade-offs
Cancer therapies often fail to cure patients because a proportion of tumor cells withstand the toxic effects of chemotherapy. How surviving cancer cells recover from sublethal drug-induced stress is not known, but given that cellular resources are finite, stress resolution may come at the expense of less essential systems. Here, we studied the global cellular… Continue reading Systems level profiling of #chemotherapy-induced stress resolution in #cancer cells reveals druggable trade-offs
#Disruption of the blood−brain barrier in 22q11.2 deletion syndrome
Neuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia. As the blood−brain barrier is the immunological interface between the brain and the periphery, we investigated whether this vascular phenotype is intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome (22qDS). Blood−brain barrier like endothelium differentiated from human 22qDS+schizophrenia-induced pluripotent… Continue reading #Disruption of the blood−brain barrier in 22q11.2 deletion syndrome
Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women
The objective of this study was to analyze changes in serum markers of bone turnover across multiple decades in osteoporotic women compared with nonosteoporotic controls, to determine their utility as potential predictors for osteoporosis. Early prediction of those at risk for osteoporosis can enable early intervention before the irreversible loss of critical bone mass. MethodsSerum… Continue reading Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women
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