Highlights•FGF1-FGFR1 signaling suppresses adipose lipolysis to curb hepatic glucose production•FGF1 suppresses lipolysis by inhibiting cAMP/PKA axis via PDE4D-S44 phosphorylation•Overexpression of PDE4D in the adipose tissue of diabetic mice corrects hyperglycemia•FGF1/PDE4D antilipolytic pathway is responsive to fed/fast states SummaryInexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously,… Continue reading FGF1 and insulin control lipolysis by convergent pathways
Impact of changing school start times on parent sleep
To examine the impact of changing school start times on sleep in parents of students in elementary, middle, and high school. MethodsAnnual surveys were completed by parents of K-12 students (n = 8190-10,592 per year) before (pre-change) and for 2 years (post-change, follow-up) after implementation of new school start times (elementary school [ES]: 60 minutes… Continue reading Impact of changing school start times on parent sleep
Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial
Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized TrialKarin Ried, Taufiq BinJemain, Avni Sali Published: November 25, 2021 (see history) DOI: 10.7759/cureus.19902 Cite this article as: Ried K, BinJemain T, Sali A (November 25, 2021) Therapies to Prevent Progression of… Continue reading Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial
Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the cortico-striatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects… Continue reading Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Early estimates of SARS-CoV-2 Omicron variant severity based on a matched cohort study, Ontario, Canada
While it is now evident that Omicron is rapidly replacing Delta, largely due to immune escape, it is less clear how the severity of Omicron compares to Delta. In Ontario, we sought to examine hospitalization and death associated with Omicron, as compared to cases infected with Delta. We conducted a matched cohort study, considering time… Continue reading Early estimates of SARS-CoV-2 Omicron variant severity based on a matched cohort study, Ontario, Canada
A novel peripheral biomarker for depression and antidepressant response
In contrast to healthy controls, the heterotrimeric G protein, Gsalpha (Gsα) is ensconced predominantly in lipid rafts in subjects with major depressive disorder (MDD) resulting in impaired stimulation of adenylyl cyclase. In this small proof-of-concept study, we examined the hypothesis that translocation of Gsα from lipid rafts toward a more facile activation of adenylyl cyclase… Continue reading A novel peripheral biomarker for depression and antidepressant response
Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
Janus kinase (JAK) inhibitors have shown encouraging results in the treatment of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and case reports. ObjectiveWe conducted a biopsy substudy during the randomized, double-blind, placebo-controlled first 24 weeks of a phase 2a clinical trial that evaluated the efficacy and safety of ritlecitinib,… Continue reading Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
Alcohol consumption and risk of ventricular arrhythmias and sudden cardiac death: An observational study of 408,712 individuals
Although previous studies have demonstrated a U-shaped relationship between alcohol and sudden cardiac death (SCD), there is a paucity of evidence on the role of alcohol specifically on incident ventricular arrhythmias (VAs). ObjectiveThe purpose of this study was to characterize associations of total and beverage-specific alcohol consumption with incident VA and SCD using data from… Continue reading Alcohol consumption and risk of ventricular arrhythmias and sudden cardiac death: An observational study of 408,712 individuals
Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicentre cohort study
Liver steatosis is becoming increasingly common in patients with chronic hepatitis B (CHB), and its effect on liver stiffness measurement (LSM), as assessed by transient elastography, remains controversial. Seven hundred and fifty-five patients with CHB and normal serum alanine aminotransferase levels, who underwent vibration-controlled transient elastography and liver biopsy, were included in the study. We… Continue reading Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicentre cohort study
2 Medical News 