Some missense gain-of-function mutations in the CACNA1C gene, encoding calcium channel CaV1.2, cause a life-threatening form of long QT syndrome (LQTS) named Timothy syndrome with currently no clinically effective therapeutics. Here we report that pharmacological targeting of sigma non-opioid intracellular receptor 1 (SIGMAR1) can restore electrophysiological function in induced pluripotent stem cell (iPSC)-derived cardiomyocytes generated… Continue reading Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome
Fourth Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC
AbstractBACKGROUND Following the emergence of the Omicron variant of concern, we investigated immunogenicity, efficacy and safety of BNT162b2 or mRNA1273 fourth dose in an open-label, clinical intervention trial. METHODS Primary end-points were safety and immunogenicity and secondary end-points were vaccine efficacy in preventing SARS-CoV-2 infections and COVID-19 symptomatic disease. The two intervention arms were compared… Continue reading Fourth Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
BackgroundTogether with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due… Continue reading Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
Health-care workers recovered from natural SARS-CoV-2 infection should be exempt frommandatory vaccination edicts
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Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline
Background and Objective: Loneliness is common and its prevalence is rising. The relationship of loneliness with subsequent dementia and the early preclinical course of Alzheimer disease and related dementia (ADRD) remains unclear. Thus, the primary objective of this study was to determine the association of loneliness with 10-year all-cause dementia risk and early cognitive and… Continue reading Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline
Immunocompromised children and young people are at no increased risk of severe COVID-19
Highlights•UK immunocompromised paediatric patients were at no increased risk of severe COVID-19. •Only 4/38 PCR detected infections were admitted to hospital. None had acute severe COVID-19 or died. •Increasing age and immunodeficiency increased reporting of SARS-CoV-2 infection. Worsening of fever, cough and sore throat were associated with reporting SARS-CoV-2 infection. •Serology results suggest there was… Continue reading Immunocompromised children and young people are at no increased risk of severe COVID-19
150 Research Studies Affirm Naturally Acquired Immunity to Covid-19: Documented, Linked, and Quoted
we should not force COVID vaccines on anyone when the evidence shows that naturally acquired immunity is equal to or more robust and superior to existing vaccines. Instead, we should respect the right of the bodily integrity of individuals to decide for themselves. Public health officials and the medical establishment with the help of the… Continue reading 150 Research Studies Affirm Naturally Acquired Immunity to Covid-19: Documented, Linked, and Quoted
Association of the Gut Microbiota With Cognitive Function in Midlife
Question Is the gut microbiota associated with cognitive function? Findings In this cross-sectional study, β-diversity, a measure of gut microbial community composition, was statistically significantly associated with all measures of cognitive function. Several specific genera were also significantly associated with 1 or more measures of cognitive function after adjustment for multiple comparisons. Meaning These results… Continue reading Association of the Gut Microbiota With Cognitive Function in Midlife
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
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