AbstractWhile inflammatory mechanisms driving hepatocellular carcinoma (HCC) had been proposed, the regulators of anti-cancer immunity in HCC remain poorly understood. We found that IL-27 receptor (IL-27R) signaling promotes HCC development in vivo. High IL-27EBI3 cytokine or IL-27RA expression correlated with poor prognosis for patients with HCC. Loss of IL-27R suppressed HCC in vivo in two… Continue reading Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
Sex differences in sequelae from COVID-19 infection and in long COVID syndrome: a review
AbstractObjectiveWe conducted literature reviews to uncover differential effects of sex on sequelae from coronavirus disease 2019 (COVID-19) and on long COVID syndrome. MethodsTwo authors independently searched OvidSP in Embase, Medline, Biosis, and Derwent Drug File. Publications reporting original, sex-disaggregated data for sequelae of COVID-19 (published before August 2020) and long COVID syndrome (published before June… Continue reading Sex differences in sequelae from COVID-19 infection and in long COVID syndrome: a review
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
BackgroundAlzheimer’s disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care. MethodsWe developed a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted MRI scans, with or without cognitive scores. For each patient, a biomarker called… Continue reading A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Establishing early diversityHumans living an urbanized lifestyle in industrialized countries tend to have less diverse microbiota than people living more rural existences. Using fecal 16S ribosomal RNA sequencing, Olm et al. found that after the first 6 months of life, the microbiome of infants living in contrasting environments diverged from Bifidobacteria-dominated assemblages. Deep metagenomic sequencing… Continue reading Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors
AbstractBackgroundThe development of covid-19 vaccinations represents a notable scientific achievement. Nevertheless, concerns have been raised regarding their possible detrimental impact on male fertility ObjectiveTo investigate the effect of covid-19 BNT162b2 (Pfizer) vaccine on semen parameters among semen donors (SD). Methods37 SD from three sperm banks that provided 220 samples, were included in that retrospective longitudinal… Continue reading Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors
Association of Accelerometer-Measured Sedentary Time and Physical Activity With Risk of Stroke Among US Adults
Importance The amount and intensity of physical activity required to prevent stroke are yet to be fully determined because of previous reliance on self-reporting measures. Furthermore, the association between objectively measured time spent being sedentary as an independent risk factor for stroke is unknown. Objective To investigate the associations of accelerometer-measured sedentary time and physical… Continue reading Association of Accelerometer-Measured Sedentary Time and Physical Activity With Risk of Stroke Among US Adults
Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth
BackgroundCoffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee consumption and miscarriage, stillbirth, birthweight, gestational age and pre-term birth using Mendelian randomization (MR). MethodsA two-sample MR study was performed using summary results data from a genome-wide association… Continue reading Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth
Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study
Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype.… Continue reading Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study
Longitudinal associations of childhood fitness and obesity profiles with midlife cognitive function: an Australian cohort study
ObjectivesClusters of low fitness and high obesity in childhood are associated with poorer health outcomes in later life, however their relationship with cognition is unknown. Identifying such profiles may inform strategies to reduce risk of cognitive decline. This study examined whether specific profiles of childhood fitness and obesity were associated with midlife cognition. DesignProspective study.… Continue reading Longitudinal associations of childhood fitness and obesity profiles with midlife cognitive function: an Australian cohort study
